Helicobacter-Induced Chronic Active Lymphoid Aggregates Have Characteristics of Tertiary Lymphoid Tissue
| Autor: | Nirah H. Shomer, Amy E. Juedes, James G. Fox, Nancy H. Ruddle |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Pathology
medicine.medical_specialty Stromal cell Lymphoid Tissue Immunology Population High endothelial venules Immunoglobulins Vascular Cell Adhesion Molecule-1 Autoimmunity Microbiology Neogenesis Helicobacter Infections Mice Mucoproteins Addressin medicine Animals CXCL13 education Cell Aggregation Hepatitis Chronic Host Response and Inflammation Antigen Presentation education.field_of_study Chemokine CCL21 biology Liver cell Membrane Proteins biology.organism_classification Chemokine CXCL13 Infectious Diseases Lymphatic system Liver Chemokines CC Antigens Surface biology.protein Parasitology Cell Adhesion Molecules Chemokines CXC |
| Zdroj: | Infection and Immunity. 71:3572-3577 |
| ISSN: | 1098-5522 0019-9567 |
| DOI: | 10.1128/iai.71.6.3572-3577.2003 |
| Popis: | Susceptible strains of mice that are naturally or experimentally infected with murine intestinal helicobacter species develop hepatic inflammatory lesions that have previously been described as chronic active hepatitis. The inflammatory infiltrates in some models of chronic autoimmunity or inflammation resemble tertiary lymphoid organs hypothesized to arise by a process termed lymphoid organ neogenesis. To determine whether hepatic inflammation caused by infection with helicobacter could give rise to tertiary lymphoid organs, we used fluorescence-activated cell sorting, immunohistochemistry, and in situ hybridization techniques to identify specific components characteristic of lymphoid organs in liver tissue sections and liver cell suspensions from helicobacter-infected mice. Small venules (high endothelial venules [HEVs]) in inflammatory lesions inHelicobacterspecies-infected livers were positive for peripheral node addressin. Mucosal addressin cell adhesion molecule also stained HEVs and cells with a staining pattern consistent with scattered stromal cells. The chemokines SLC (CCL 21) and BLC (CXCL13) were present, as were B220-positive B cells and T cells. The latter included a naïve (CD45lo-CD62Lhi) population. These findings suggest that helicobacter-induced chronic active hepatitis arises through the process of lymphoid organ neogenesis. |
| Databáze: | OpenAIRE |
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