Increased total sodium concentration in gray matter better explains cognition than atrophy in MS

Autor: Maxime Guye, Fanelly Pariollaud, Soraya Gherib, Audrey Rico, Wafaa Zaaraoui, Bertrand Audoin, Jean-Philippe Ranjeva, Lothar R. Schad, Jean Pelletier, Sylviane Confort-Gouny, Elisabeth Soulier, Adil Maarouf
Přispěvatelé: Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Maison Blanche, Centre Hospitalier Universitaire de Reims (CHU Reims), Centre d'Exploration Métabolique par Résonance Magnétique [Hôpital de la Timone - APHM] (CEMEREM), Hôpital de la Timone [CHU - APHM] (TIMONE)-Centre de résonance magnétique biologique et médicale (CRMBM), Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)-Centre National de la Recherche Scientifique (CNRS), Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Assistance Publique - Hôpitaux de Marseille (APHM), Centre d'Exploration Métabolique par Résonance Magnétique [Marseille] (CEMEREM), Hôpital de la Timone [CHU - APHM] (TIMONE)
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Adult
Male
medicine.medical_specialty
Neuropsychological Tests
Tritium
Gastroenterology
Statistics
Nonparametric

030218 nuclear medicine & medical imaging
White matter
Disability Evaluation
03 medical and health sciences
Multiple Sclerosis
Relapsing-Remitting

0302 clinical medicine
Atrophy
Internal medicine
crmbm
medicine
Humans
Gray Matter
10. No inequality
Cognitive deficit
Expanded Disability Status Scale
Receiver operating characteristic
medicine.diagnostic_test
Multiple sclerosis
Sodium
Case-control study
Magnetic resonance imaging
Middle Aged
medicine.disease
Magnetic Resonance Imaging
medicine.anatomical_structure
Case-Control Studies
Disease Progression
Female
[SDV.IB]Life Sciences [q-bio]/Bioengineering
Neurology (clinical)
medicine.symptom
Cognition Disorders
Psychology
Neuroscience
030217 neurology & neurosurgery
Zdroj: Neurology
Neurology, 2016, ⟨10.1212/WNL.0000000000003511⟩
Neurology, American Academy of Neurology, 2016, ⟨10.1212/WNL.0000000000003511⟩
ISSN: 0028-3878
1526-632X
DOI: 10.1212/WNL.0000000000003511⟩
Popis: Objective:To investigate whether brain total sodium accumulation assessed by 23Na MRI is associated with cognitive deficit in relapsing-remitting multiple sclerosis (RRMS).Methods:Eighty-nine participants were enrolled in the study (58 patients with RRMS with a disease duration ≤10 years and 31 matched healthy controls). Patients were classified as cognitively impaired if they failed at least 2 tasks on the Brief Repeatable Battery. MRI was performed at 3T using 23Na MRI to obtain total sodium concentration (TSC) in the different brain compartments (lesions, normal-appearing white matter [NAWM], gray matter [GM]) and 1H- magnetization-prepared rapid gradient echo to assess GM atrophy (GM fraction).Results:The mean disease duration was 3.1 years and the median Expanded Disability Status Scale score was 1 (range 0–4.5). Thirty-seven patients were classified as cognitively preserved and 21 as cognitively impaired. TSC was increased in GM and NAWM in cognitively impaired patients compared to cognitively preserved patients and healthy controls. Voxel-wise analysis demonstrated that sodium accumulation was mainly located in the neocortex in cognitively impaired patients. Regression analysis evidenced than the 2 best independent predictors of cognitive impairment were GM TSC and age. Receiver operating characteristic analyses demonstrated that sensitivity and specificity of the GM TSC to classify patients according to their cognitive status were 76% and 71%, respectively.Conclusions:This study provides 2 main findings. (1) In RRMS, total sodium accumulation in the GM is better associated with cognitive impairment than GM atrophy; and (2) total sodium accumulation in patients with cognitive impairment is mainly located in the neocortex.
Databáze: OpenAIRE
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