Hypoglycemia Induces Mitochondrial Reactive Oxygen Species Production Through Increased Fatty Acid Oxidation and Promotes Retinal Vascular Permeability in Diabetic Mice

Autor: Nobuhiro Kajihara, Takeshi Matsumura, Hiroyuki Motoshima, Daisuke Kukidome, Eiichi Araki, Ayaka Yoshinaga, Takeshi Nishikawa
Rok vydání: 2020
Předmět:
0301 basic medicine
Mitochondrial ROS
Vascular Endothelial Growth Factor A
medicine.medical_specialty
Physiology
Clinical Biochemistry
Vascular permeability
Mice
Transgenic
Hypoglycemia
Biochemistry
Retina
Streptozocin
Diabetes Mellitus
Experimental
Capillary Permeability
03 medical and health sciences
chemistry.chemical_compound
Mice
Internal medicine
Blood-Retinal Barrier
medicine
Animals
Humans
Molecular Biology
Beta oxidation
Cells
Cultured
General Environmental Science
chemistry.chemical_classification
Reactive oxygen species
Diabetic Retinopathy
030102 biochemistry & molecular biology
Superoxide Dismutase
Fatty Acids
Endothelial Cells
Retinal
Diabetic mouse
Cell Biology
Diabetic retinopathy
medicine.disease
Mitochondria
Disease Models
Animal
030104 developmental biology
Endocrinology
chemistry
Gene Expression Regulation
General Earth and Planetary Sciences
Reactive Oxygen Species
Zdroj: Antioxidantsredox signaling. 34(16)
ISSN: 1557-7716
Popis: Aims: Hypoglycemia is associated with increased reactive oxygen species (ROS) production and vascular events. We have previously reported that low-glucose (LG) conditions induce mitochondrial ROS (...
Databáze: OpenAIRE
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