Bovine Thrombin Induces an Acquired Coagulopathy in Sensitized Patients Undergoing Revision Spinal Surgery: A Report of Two Cases
| Autor: | Sean E. McCance, Patrick F. O’Leary, Mark C. Nelson, Randy L. Levine, Ashley R. Poynton |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Reoperation medicine.medical_specialty Factor V Deficiency Spinal Stenosis Thrombin medicine Coagulopathy Humans Orthopedics and Sports Medicine Kyphosis Clotting factor biology business.industry Factor V Middle Aged Acquired Factor V Deficiency medicine.disease Orthopedic Fixation Devices Surgery Cardiac surgery Spinal Fusion Coagulation Anesthesia Prothrombin Time biology.protein Female Neurology (clinical) business medicine.drug |
| Zdroj: | Spine. 28:E221-E223 |
| ISSN: | 0362-2436 |
| DOI: | 10.1097/01.brs.0000065491.60871.06 |
| Popis: | STUDY DESIGN A report of two cases is presented. OBJECTIVE To raise awareness of bovine thrombin-induced factor V deficiency. SUMMARY OF BACKGROUND DATA Bovine thrombin is a frequently used hemostatic agent in spinal surgery. Current preparations contain clotting factors in addition to thrombin, particularly factor V, which are immunogenic. Re-exposure of sensitized patients to bovine thrombin products during subsequent surgery may lead to the formation of antibodies that cross-react with human clotting factors, most commonly against factor V. Hemorrhagic complications have been reported in nonspinal patients due to a bovine thrombin-induced factor V deficiency. METHODS Two spinal cases are reported, and the literature is reviewed. RESULTS In the cases outlined, both patients underwent revision spinal surgery, with re-exposure to bovine thrombin. Both patients developed abnormal coagulation profiles, with an acquired factor V deficiency. No hemorrhagic complications occurred; however, second-stage surgery was delayed in one patient and not undertaken in the other. In both patients, the coagulopathy resolved spontaneously. CONCLUSIONS Bovine thrombin-induced coagulopathy is well recognized in cardiac surgery but has not been reported in spinal surgical patients. Data available from cardiac surgical patients suggests that those who are sensitized to two or more bovine clotting factors are at greatest risk of hemorrhagic complications. The cases we present demonstrate that this phenomenon occurs in spinal surgical patients and serve to raise awareness of the potential danger of bovine thrombin in sensitized patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|