Expression of the herpes simplex virus type 2 latency-associated transcript enhances spontaneous reactivation of genital herpes in latently infected guinea pigs
| Autor: | Lawrence R. Stanberry, Amita Patel, Jumana F. Kurawadwala, Sharon E. Straus, Philip R. Krause, Nigel Bourne, Beverly L. Connelly |
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| Jazyk: | angličtina |
| Rok vydání: | 1995 |
| Předmět: |
Gene Expression Regulation
Viral Genes Viral viruses Herpesvirus 2 Human Immunology Guinea Pigs Molecular Sequence Data Restriction Mapping Caviidae medicine.disease_cause Virus Replication Gene product Tissue culture Latent Virus Recurrence Virus latency medicine Immunology and Allergy Animals Promoter Regions Genetic Herpes Genitalis DNA Primers Viral Structural Proteins biology Base Sequence Articles biology.organism_classification medicine.disease Virology Virus Latency Herpes simplex virus Viral replication Acute Disease DNA Viral |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| Popis: | The latency-associated transcript (LAT) is the only herpes simplex virus (HSV) gene product detectable in latently infected humans and animals. In this report, we show that a 624-bp deletion in the promoter of the HSV-2 LAT had no discernable effect on viral growth in tissue culture or in acute genital infection of guinea pigs, but impaired LAT accumulation and led to a marked decrease in spontaneous genital recurrences when compared with the behavior of wild-type and rescuant strains. Differences in the ability of the mutant to replicate, or in how readily it established or maintained latency did not account for this finding. Thus, HSV LAT expression facilitates the spontaneous reactivation of latent virus. |
| Databáze: | OpenAIRE |
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