Intestinal Availability and Metabolic Effects of Dietary Camelina Sphingolipids during the Metabolic Syndrome Onset in Mice
| Autor: | Marta Grausso Culetto, Dominique Hermier, Anne Blais, Lionel Gissot, Frédérique Tellier, Annaïg Lan, Jean-Denis Faure, Philippe Schmidely, Véronique Mathé, Yannick Bellec |
|---|---|
| Přispěvatelé: | Physiologie de la Nutrition et du Comportement Alimentaire (PNCA (UMR 0914)), AgroParisTech-Université Paris-Saclay-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut Jean-Pierre Bourgin (IJPB), Modélisation Systémique Appliquée aux Ruminants (MoSAR) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
[SDV.BIO]Life Sciences [q-bio]/Biotechnology 030309 nutrition & dietetics Camelina sativa Inflammation acyl chain metabolic syndrome [SDV.GEN.GPL]Life Sciences [q-bio]/Genetics/Plants genetics 03 medical and health sciences Insulin resistance Internal medicine medicine [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM] Barrier function 030304 developmental biology 2. Zero hunger 0303 health sciences Meal biology food and beverages [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology General Chemistry biology.organism_classification medicine.disease Sphingolipid Camelina 3. Good health [SDV.BV.AP]Life Sciences [q-bio]/Vegetal Biology/Plant breeding Endocrinology digestibility lipids (amino acids peptides and proteins) sphingolipid medicine.symptom Metabolic syndrome General Agricultural and Biological Sciences |
| Zdroj: | Journal of Agricultural and Food Chemistry Journal of Agricultural and Food Chemistry, American Chemical Society, 2020, 68 (3), pp.788-798. ⟨10.1021/acs.jafc.9b06829⟩ |
| ISSN: | 0021-8561 1520-5118 |
| Popis: | International audience; Sphingolipids appear as a promising class of components susceptible to prevent the onset of the metabolic syndrome (MetS). Gut availability and effects of Camelina sativa sphingolipids were investigated in a mouse model of dietary-induced MetS. Seed meals from two Camelina sativa lines enriched, respectively, in C24-and C16-NH 2 − glycosyl-inositol-phosphoryl-ceramides (NH 2 GIPC) were used in hypercaloric diets. After 5 weeks on these two hypercaloric diets, two markers of the MetS were alleviated (adiposity and insulin resistance) as well as inflammation markers and colon barrier dysfunction. A more pronounced effect was observed with the C16-NH 2 GIPC-enriched HC diet, in particular for colon barrier function. Despite a lower digestibility, C16-NH 2 GIPC were more prevalent in the intestine wall. Sphingolipids provided as camelina meal can therefore counteract some deleterious effects of a hypercaloric diet in mice at the intestinal and systemic levels. Interestingly, these beneficial effects seem partly dependent on sphingolipid acyl chain length. |
| Databáze: | OpenAIRE |
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