Influence of zinc on onset and progression of oral carcinogenesis in rats
| Autor: | Kjell Wallenius, M. Abdulla, Arun Mathur |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Male
medicine.medical_specialty chemistry.chemical_element Zinc medicine.disease_cause Internal medicine Mole medicine Animals General Dentistry Carcinogen Plasma zinc Chemistry Mouth Mucosa Neoplasms Experimental General Medicine Copper 4-Nitroquinoline-1-oxide Rats Endocrinology Female Mouth Neoplasms Histopathology Palate Soft Carcinogenesis |
| Zdroj: | Acta Odontologica Scandinavica. 37:277-284 |
| ISSN: | 1502-3850 0001-6357 |
| DOI: | 10.3109/00016357909004697 |
| Popis: | Three-week-old female rats were fed 0.09 (zinc-deficient), 0.77 (zinc-adequate) or 3.98 (zinc-supplemented) mmol zinc/kg diet in three experimental groups and the palatal mucosa was painted with the water-soluble carcinogen 4-nitroquinoline N-oxide (4NQO) three times a week for 20 weeks. The zinc-supplemented diet seemed to retard the induction of carcinogenesis, whereas a low-zinc diet had the opposite effect. Once initial cellular changes had been induced the supplementary zinc seemed to accelerate their further advancement. Zinc-deficiency in animals fed a copper/zinc low-zinc diet was reflected in the plasma and liver zinc levels as well as in the copper/zinc ratio. The development of cancer was accompanied by a decrease in plasma zinc and an increase in the plasma copper/zinc ratio as well as in the liver zinc. These changes were most remarkable in the zinc-supplemented group. |
| Databáze: | OpenAIRE |
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