Minimal interval defined on 7q in uterine leiomyoma
| Autor: | John Gewin, Christine Tullis, Chun-Yan Song, Darcy Stracner, Susan M. Sell |
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| Rok vydání: | 2005 |
| Předmět: |
Abdominal discomfort
Chromosome 7 (human) Cancer Research Pathology medicine.medical_specialty Genetic Anomaly Uterine leiomyoma Leiomyoma Uterine leiomyomata Uterine prolapse Anatomy Biology medicine.disease Tumor tissue Asymptomatic Uterine Neoplasms Genetics medicine Humans Female medicine.symptom Molecular Biology Chromosomes Human Pair 7 |
| Zdroj: | Cancer Genetics and Cytogenetics. 157:67-69 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/j.cancergencyto.2004.06.007 |
| Popis: | Uterine leiomyomata are benign, smooth-muscle tumors. The tumors are very common, affecting approximately 10-15 million women in the United States annually. Uterine leiomyomata are often asymptomatic, but may cause symptoms that range in severity from mild abdominal discomfort to uterine prolapse. Several different chromosomal aberrations have been found in the tumor tissue. Because of the common occurrence of this tumor and the potential severity of associated sequelae, research delineating the different molecular subtypes is needed. Deletions on the long arm of chromosome 7 are believed to be the most common genetic anomaly in uterine leiomyoma. The size of the deletion varies, which makes it difficult to identify the genes that, upon deletion, contribute to tumor growth. The smallest previously defined interval was12,000 kb. We have narrowed a minimal region to an interval of500 kb. |
| Databáze: | OpenAIRE |
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