An individual with human immunodeficiency virus, dementia, and central nervous system amyloid deposition
| Autor: | Giuseppe Esposito, Gary L. Simon, Wesley A. Horton, Raymond Scott Turner, Melanie Chadwick, Xiong Jiang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Central nervous system Precuneus HAND HIV-associated neurocognitive disorder 03 medical and health sciences 0302 clinical medicine mental disorders medicine Dementia RC346-429 Florbetaben Diagnostic Assessment & Prognosis Functional MRI Resting state fMRI Human immunodeficiency virus RC952-954.6 HIV Biomarker Alzheimer's disease medicine.disease Psychiatry and Mental health 030104 developmental biology medicine.anatomical_structure Geriatrics Amyloid PET Posterior cingulate Hypermetabolism Neurology. Diseases of the nervous system Neurology (clinical) Psychology HIV‐associated neurocognitive disorder 030217 neurology & neurosurgery |
| Zdroj: | Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 4, Iss 1, Pp 1-5 (2016) |
| ISSN: | 2352-8729 |
| DOI: | 10.1016/j.dadm.2016.03.009 |
| Popis: | Human immunodeficiency virus (HIV)–associated neurocognitive disorder (HAND) is found in 30%–50% of individuals with HIV infection. To date, no HIV+ individual has been reported to have a positive amyloid PET scan. We report a 71‐year‐old HIV+ individual with HAND. Clinical and neuropsychologic evaluations confirmed a progressive mild dementia. A routine brain MRI was normal for age. [18F]Fluorodeoxyglucose–PET revealed mild hypermetabolism in bilateral basal ganglia and hypometabolism of bilateral parietal cortex including the posterior cingulate/precuneus. Resting state functional MRI revealed altered connectivity as found with individuals with mild AD. CSF examination revealed a low Aβ42/tau index but a low phospho‐tau. An amyloid PET/CT with [18F]florbetaben revealed pronounced cortical radiotracer deposition. This case report suggests that progressive dementia in older HIV+ individuals may be due to HAND, AD, or both. HIV infection does not preclude CNS Aβ/amyloid deposition. Amyloid PET imaging may be of value in distinguishing HAND from AD pathologies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text