Design of and rationale for the Japan Diabetes Optimal Integrated Treatment study for 3 major risk factors of cardiovascular diseases (J-DOIT3): a multicenter, open-label, randomized, parallel-group trial
| Autor: | Ai Morita, Kazuo Hara, Mitsuhiko Noda, Sumie Okahata, Yasuo Ohashi, Masayuki Kato, Yukiko Okazaki, Ken Ohashi, Kohjiro Ueki, Mikiko Haraguchi, Takayoshi Sasako, Hisayuki Katsuyama, Takashi Kadowaki, Kazuo Izumi, Atsushi Morise |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Cardiovascular and Metabolic Risk Endocrinology Diabetes and Metabolism Type 2 diabetes 030204 cardiovascular system & hematology Bioinformatics Multifactorial Interventions law.invention Weight Control 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial law Diabetes mellitus Internal medicine medicine Clinical endpoint 030212 general & internal medicine business.industry Guideline medicine.disease Lifestyle Modification Blood pressure chemistry Intensified Therapy Glycated hemoglobin business Dyslipidemia |
| Zdroj: | BMJ Open Diabetes Research & Care |
| ISSN: | 2052-4897 |
| Popis: | Objective Multifactorial intervention including the management of levels of blood glucose (BG), blood pressure (BP), and lipids has been suggested to decrease cardiovascular disease (CVD) risk. However, the target ideal and feasible levels for these individual parameters have not been fully evaluated. In this study, we examine the hypothesis that stricter control compared with the current targets in the Japanese guideline for BG, BP, and lipids could efficiently and safely reduce CVD risk. Research Design and Methods We screened patients with type 2 diabetes and hypertension and/or dyslipidemia among 81 hospitals in Japan and allocated them into 2 groups: the intensive therapy group (ITG) and the conventional therapy group (CTG). For the 2 respective groups, the target for glycated hemoglobin (HbA1c) is |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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