Mammalian phosphatidylinositol 4-kinases as modulators of membrane trafficking and lipid signaling networks
| Autor: | Shane Minogue, Emma L. Clayton, Mark G. Waugh |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
FAAT motif
two phenylalanines in an acidic tract motif SARS Severe acute respiratory syndrome TRPV transient receptor potential vanilloid Lipid kinase activity Review Biochemistry Receptors G-Protein-Coupled FAPP2 Four-phosphate adaptor protein 2 chemistry.chemical_compound 0302 clinical medicine Phosphatidylinositol Phosphates Neoplasms 1-Phosphatidylinositol 4-Kinase ARF ADP-ribosylation factor 0303 health sciences Kinase Intracellular vesicle Bacterial Infections 3. Good health Cell biology Sphingomyelins PI4P phosphatidylinositol 4-phosphate Pleckstrin homology domain Isoenzymes PKD protein kinase D Virus Diseases HCV hepatitis C virus PI(3 4 5)P3 phosphatidylinositol (3 4 5)-trisphosphate OSBP oxysterol binding protein Signal Transduction PH pleckstrin homology Biology Glycosphingolipids PI phosphatidylinositol ER endoplasmic reticulum 03 medical and health sciences PLC phospholipase C PI(4 5)P2 phosphatidylinositol (4 5)-bisphosphate Animals Humans NCS-1 neuronal calcium sensor-1 Phosphatidylinositol OSH oxysterol binding protein homologue 030304 developmental biology G protein-coupled receptor GPCR G-protein-coupled receptor TGN trans Golgi network EGF epidermal growth factor Cell Biology EGFR epidermal growth factor receptor chemistry Nervous System Diseases DAG diacylglycerol 030217 neurology & neurosurgery Phosphoinositide-dependent kinase-1 |
| Zdroj: | Progress in Lipid Research |
| ISSN: | 0163-7827 |
| DOI: | 10.1016/j.plipres.2013.04.002 |
| Popis: | The four mammalian phosphatidylinositol 4-kinases modulate inter-organelle lipid trafficking, phosphoinositide signalling and intracellular vesicle trafficking. In addition to catalytic domains required for the synthesis of PI4P, the phosphatidylinositol 4-kinases also contain isoform-specific structural motifs that mediate interactions with proteins such as AP-3 and the E3 ubiquitin ligase Itch, and such structural differences determine isoform-specific roles in membrane trafficking. Moreover, different permutations of phosphatidylinositol 4-kinase isozymes may be required for a single cellular function such as occurs during distinct stages of GPCR signalling and in Golgi to lysosome trafficking. Phosphatidylinositol 4-kinases have recently been implicated in human disease. Emerging paradigms include increased phosphatidylinositol 4-kinase expression in some cancers, impaired functioning associated with neurological pathologies, the subversion of PI4P trafficking functions in bacterial infection and the activation of lipid kinase activity in viral disease. We discuss how the diverse and sometimes overlapping functions of the phosphatidylinositol 4-kinases present challenges for the design of isoform-specific inhibitors in a therapeutic context. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect