Down-regulated MYH11 Expression Correlates with Poor Prognosis in Stage II and III Colorectal Cancer
| Autor: | J Peng, Hong Fen Lu, Ren Jie Wang, Peng Wu, Guo Xiang Cai, Wei Qi Sheng, Zhi Min Wang, Ye Xu, San Jun Cai |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Cancer Research Epidemiology Lymphovascular invasion Colorectal cancer Perineural invasion Down-Regulation Biology Real-Time Polymerase Chain Reaction Disease-Free Survival Gene expression medicine Humans RNA Messenger Aged Neoplasm Staging Regulation of gene expression Univariate analysis Myosin Heavy Chains Carcinoma Public Health Environmental and Occupational Health Prognosis medicine.disease Immunohistochemistry Gene Expression Regulation Neoplastic Real-time polymerase chain reaction Oncology Cancer research Female Colorectal Neoplasms |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 15:7223-7228 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2014.15.17.7223 |
| Popis: | The MYH11 gene may be related to cell migration and adhesion, intracellular transport, and signal transduction. However, its relationship with prognosis is still uncertain. The aim of this study was to investigate correlations between MYH11 gene expression and prognosis in 58 patients with stage II and III colorectal cancer. Quantitative real-time polymerase chain reaction was performed in fresh CRC tissues to examine mRNA expression, and immunohistochemistry was performed with paraffin-embedded specimens for protein expression. On univariate analysis, MYH11 expression at both mRNA and protein levels, perineural invasion and lymphovascular invasion were related to disease-free survival (p |
| Databáze: | OpenAIRE |
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