Responses of pulmonary vagal mechanoreceptors to high-frequency oscillatory ventilation
| Autor: | J. A. Wozniak, P. C. Kosch, Paul W. Davenport |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
Functional Residual Capacity Physiology medicine.medical_treatment High-Frequency Ventilation Dogs Functional residual capacity Pulmonary stretch receptors Physiology (medical) Internal medicine Animals Medicine Lung biology business.industry Fissipedia High-frequency ventilation Vagus Nerve respiratory system biology.organism_classification Vagus nerve Mechanoreceptor Autonomic nervous system Pulmonary Stretch Receptors medicine.anatomical_structure Anesthesia Breathing Cardiology business Mechanoreceptors |
| Zdroj: | Journal of Applied Physiology. 65:633-639 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/jappl.1988.65.2.633 |
| Popis: | The discharge of 57 slowly adapting pulmonary stretch receptors (PSR's) and 16 rapidly adapting receptors (RAR's) was recorded from thin vagal filaments in anesthetized dogs. The receptors were localized and separated into three groups: extrathoracic tracheal, intrathoracic tracheal, and intrapulmonary receptors. The influence of high-frequency oscillatory ventilation (HFO) at 29 Hz on receptor discharge was analyzed by separating the response to the associated shift in functional residual capacity (FRC) from the oscillatory component of the response. PSR activity during HFO was increased from spontaneous breathing (49%) and from the static FRC shift (25%). PSR activity during the static inflation was increased 19% over spontaneous breathing. RAR activity was also increased with HFO. These results demonstrate that 1) the increased activity of PSR and RAR during HFO is due primarily to the oscillating action of the ventilator and secondarily to the shift in FRC associated with HFO, 2) the increased PSR activity during HFO may account for the observed apneic response, and 3) PSR response generally decreases with increasing distance from the tracheal opening. |
| Databáze: | OpenAIRE |
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