The trypanosome alternative oxidase: a potential drug target?
| Autor: | Terry K. Smith, Stefanie K. Menzies, Gordon J. Florence, Lindsay B. Tulloch |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Drug Alternative oxidase media_common.quotation_subject Trypanosoma brucei brucei 030231 tropical medicine Drug target Computational biology Trypanosoma brucei Mitochondrion Pharmacology Mitochondrial Proteins 03 medical and health sciences 0302 clinical medicine In vivo Drug Discovery medicine Animals Humans African trypanosomiasis Plant Proteins media_common biology Drug discovery biology.organism_classification medicine.disease Trypanocidal Agents Mitochondria Trypanosomiasis African 030104 developmental biology Infectious Diseases Animal Science and Zoology Parasitology Oxidoreductases |
| Zdroj: | Parasitology. 145:175-183 |
| ISSN: | 1469-8161 0031-1820 |
| DOI: | 10.1017/s0031182016002109 |
| Popis: | SUMMARYNew drugs againstTrypanosoma brucei,the causative agent of Human African Trypanosomiasis, are urgently needed to replace the highly toxic and largely ineffective therapies currently used. The trypanosome alternative oxidase (TAO) is an essential and unique mitochondrial protein in these parasites and is absent from mammalian mitochondria, making it an attractive drug target. The structure and function of the protein are now well characterized, with several inhibitors reported in the literature, which show potential as clinical drug candidates. In this review, we provide an update on the functional activity and structural aspects of TAO. We then discuss TAO inhibitors reported to date, problems encountered within vivotesting of these compounds, and discuss the future of TAO as a therapeutic target. |
| Databáze: | OpenAIRE |
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