Collagen Peptide Presenting Nanofibrous Scaffold for Intervertebral Disc Regeneration
| Autor: | Hakan Özalp, Yusuf Sukru Caglar, Mustafa O. Guler, Ozge Uysal, Mustafa Cemil Kilinc, Gulcihan Gulseren, Ihsan Dogan, Elif Arslan, Ayse B. Tekinay |
|---|---|
| Přispěvatelé: | Uysal, Özge, Arslan, Elif, Gülseren, Gülcihan, Tekinay, Ayşe B. |
| Rok vydání: | 2019 |
| Předmět: |
musculoskeletal diseases
Needle puncture model Biomedical Engineering Dentistry Biomaterials Lumbar health services administration Back pain medicine Regeneration Peptide nanofiber Occupational disability Collagen peptide business.industry Regeneration (biology) Biochemistry (medical) Intervertebral disc General Chemistry musculoskeletal system medicine.anatomical_structure population characteristics Collagen Nanofibrous scaffold Intervertebral disc degeneration medicine.symptom business |
| Zdroj: | ACS Applied Bio Materials |
| ISSN: | 2576-6422 |
| DOI: | 10.1021/acsabm.9b00062 |
| Popis: | Lower back pain (LBP) is a prevalent spinal symptom at the lumbar region of the spine, which severely effects quality of life and constitutes the number one cause of occupational disability. Degeneration of the intervertebral disc (IVD) is one of the well-known causes contributing to the LBP. Therapeutic biomaterials inducing IVD regeneration are promising candidates for IVD degeneration treatments. Here, we demonstrate a collagen peptide presenting nanofiber scaffold to mimic the structure and function of the natural extracellular matrix of the tissue for IVD regeneration. The collagen peptide presenting nanofiber was designed by using a Pro-Hyp-Gly (POG) peptide sequence on a self-assembling peptide amphiphile molecule, which assembled into nanofibers forming scaffolds. Injection of collagen peptide presenting peptide nanofiber scaffold into the degenerated rabbit IVDs induced more glycosaminoglycan and collagen deposition compared to controls. Functional recovery of the tissue was evaluated by degeneration index score, where the bioactive scaffold was shown to provide functional recovery of the IVD degeneration. These results showed that the collagen peptide presenting nanofiber scaffold can prevent the progression of IVD degeneration and provide further functional recovery of the tissue. |
| Databáze: | OpenAIRE |
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