Effect of TIM-3 Blockade on the Immunophenotype and Cytokine Profile of Murine Uterine NK Cells
| Autor: | Brian Smith, Indira Guleria, Pranal J. Dakle, Lola Chabtini, Sudipta Tripathi, Hisaya Akiba, Hideo Yagita |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Chemokine medicine.medical_treatment Lymphocyte Placenta Population lcsh:Medicine Histocompatibility Maternal-Fetal Immune tolerance Immunophenotyping Pregnancy Immune Tolerance Medicine Animals Antigens Ly education lcsh:Science Hepatitis A Virus Cellular Receptor 2 Cells Cultured Interleukin-15 education.field_of_study Multidisciplinary CD11b Antigen biology business.industry lcsh:R Uterus Granulocyte-Macrophage Colony-Stimulating Factor 3. Good health Cell biology Blockade Killer Cells Natural Mice Inbred C57BL Cytokine medicine.anatomical_structure Granulocyte macrophage colony-stimulating factor Interleukin 15 Immunology embryonic structures biology.protein Mice Inbred CBA Receptors Virus lcsh:Q Female Chemokines business medicine.drug Research Article |
| Zdroj: | PLoS ONE PLoS ONE, Vol 10, Iss 4, p e0123439 (2015) |
| ISSN: | 1932-6203 |
| Popis: | NK cells are the most abundant lymphocyte population in the feto-maternal interface during gestation. The uterine NK cells (uNK) are transient, have a unique immunophenotype and produce a number of cytokines. These cytokines play an important role in establishment and maintenance of vascular remodeling and tolerance associated with successful pregnancy. The uNK cells also express TIM-3 during gestation and blockade of TIM-3 expression results in fetal loss in mice. In this study we determined the effect of TIM-3 blockade on uNK cells. Specifically we observed surface receptor phenotype and cytokine production by uNK cells following TIM-3 blockade. Our results show that TIM-3 plays a role in regulating the uNK cells and contributes to the maintenance of tolerance at the feto-maternal interface. |
| Databáze: | OpenAIRE |
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