Animal models for SARS-CoV-2 research: A comprehensive literature review

Autor: Arpan Acharya, St Patrick Reid, Kabita Pandey, Siddappa N. Byrareddy, Mahesh Mohan, Caroline L. Ng
Rok vydání: 2020
Předmět:
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
040301 veterinary sciences
Middle East respiratory syndrome coronavirus
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
viruses
medicine.disease_cause
Article
0403 veterinary science
03 medical and health sciences
Pandemic
medicine
Animals
Humans
Intensive care medicine
skin and connective tissue diseases
Pandemics
030304 developmental biology
Coronavirus
0303 health sciences
General Veterinary
General Immunology and Microbiology
Transmission (medicine)
business.industry
SARS-CoV-2
Public health
fungi
virus diseases
COVID-19
04 agricultural and veterinary sciences
General Medicine
respiratory tract diseases
Severe acute respiratory syndrome-related coronavirus
Models
Animal
Molecular mechanism
Middle East Respiratory Syndrome Coronavirus
business
Zdroj: Transbound Emerg Dis
Transboundary and Emerging Diseases
ISSN: 1865-1682
Popis: Emerging and re-emerging viral diseases can create devastating effects on human lives and may also lead to economic crises. The ongoing COVID-19 pandemic due to the novel coronavirus (nCoV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in Wuhan, China, has caused a global public health emergency. To date, the molecular mechanism of transmission of SARS-CoV-2, its clinical manifestations and pathogenesis is not completely understood. The global scientific community has intensified its efforts in understanding the biology of SARS-CoV-2 for development of vaccines and therapeutic interventions to prevent the rapid spread of the virus and to control mortality and morbidity associated with COVID-19. To understand the pathophysiology of SARS-CoV-2, appropriate animal models that mimic the biology of human SARS-CoV-2 infection are urgently needed. In this review, we outline animal models that have been used to study previous human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and middle east respiratory syndrome coronavirus (MERS-CoV). Importantly, we discuss models that are appropriate for SARS-CoV-2 as well as the advantages and disadvantages of various available methods.
Databáze: OpenAIRE
Externí odkaz: