Regional glucose metabolic reduction in dementia with Lewy bodies is independent of amyloid deposition
| Autor: | Kenji Shimamoto, Makoto Hosono, Tomoko Hyodo, Chisa Hosokawa, Kazunari Ishii, Kenta Sakaguchi, Kimio Usami, Takamichi Murakami, Yuzuru Yamazoe |
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| Rok vydání: | 2014 |
| Předmět: |
Lewy Body Disease
Male Pathology medicine.medical_specialty Amyloid Dementia with Lewy bodies Brain mapping behavioral disciplines and activities 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Fluorodeoxyglucose F18 mental disorders Medicine Humans Radiology Nuclear Medicine and imaging Benzothiazoles Radionuclide Imaging Aged Aged 80 and over Brain Mapping Glucose metabolism Aniline Compounds business.industry Amyloid deposit Brain General Medicine medicine.disease nervous system diseases Thiazoles Amyloid deposition Glucose PET nervous system Radiology Nuclear Medicine and imaging Female Original Article Alzheimer's disease Radiopharmaceuticals Lewy body disease business 030217 neurology & neurosurgery |
| Zdroj: | Annals of Nuclear Medicine |
| ISSN: | 1864-6433 |
| Popis: | Purpose There is evidence that some cases of patients with dementia with Lewy bodies (DLB) can demonstrate Alzheimer disease (AD) like reduced glucose metabolism without amyloid deposition. The aim of this study was to clarify whether regional hypometabolism is related to amyloid deposits in the DLB brain and measure the degree of regional hypometabolism. Methods Ten consecutive subjects with DLB and 10 AD patients who underwent both Pittsburgh compound B (PiB)-PET and 18F-fluoro-2-deoxyglucose (FDG)-PET were included in this study. Regional standardized uptake value ratio (SUVR)s normalised to cerebellar cortices were calculated in the FDG- and PiB-PET images. Results All AD patients and five DLB patients showed amyloid deposits (PiB positive). In the DLB group the parietotemporal and occipital metabolism were significantly lower than those in the AD group but there was no difference between the posterior cingulate hypometabolism between DLB and AD groups. There were no differences in regional glucose metabolism between PiB positive and negative DLB patients. Conclusions In the DLB brain, it is suggested that decreased regional glucose metabolism is unrelated to amyloid deposits, although the hypometabolic area overlaps with the AD hypometabolic area and the degree of parietotemporal and occipital hypometabolism in DLB brain is much larger than that in AD brain. |
| Databáze: | OpenAIRE |
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