Topical Application of Cinnamaldehyde Promotes Faster Healing of Skin Wounds Infected with Pseudomonas aeruginosa
| Autor: | Elizabeth S. Fernandes, Laoane F. Gonzaga, João Francisco Silva Rodrigues, Thiago Azevedo Feitosa Ferro, Eliene B. Souza, João B. Calixto, Eunice André, Maria Rosa Quaresma Bomfim, Márcia C.A.M. Machado, Mariela A. M. Suarez, Saulo J. F. Mendes, Valério Monteiro-Neto, Jack L. Arbiser, Domingos M. S. Pereira |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
skin wound
Pharmaceutical Science wound healing Pharmacology medicine.disease_cause Cinnamaldehyde Analytical Chemistry Nitric oxide lcsh:QD241-441 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine lcsh:Organic chemistry Drug Discovery medicine Physical and Theoretical Chemistry 030304 developmental biology 0303 health sciences integumentary system Pseudomonas aeruginosa business.industry cinnamaldehyde Organic Chemistry Biofilm Antimicrobial Haemolysis Vascular endothelial growth factor chemistry Chemistry (miscellaneous) 030220 oncology & carcinogenesis Molecular Medicine Wound healing business |
| Zdroj: | Molecules, Vol 24, Iss 8, p 1627 (2019) Molecules Volume 24 Issue 8 |
| ISSN: | 1420-3049 |
| Popis: | Wound healing can be delayed following colonization and infection with the common bacterium Pseudomonas aeruginosa. While multiple therapies are used for their treatment, these are ineffective, expensive, and labour-intensive. Thus, there is an enormous unmet need for the treatment of infected wounds. Cinnamaldehyde, the major component of cinnamon oil, is well known for its antimicrobial properties. Herein, we investigated the effects of sub-inhibitory concentrations of cinnamaldehyde in the virulence of P. aeruginosa. We also assessed its healing potential in P. aeruginosa-infected mouse skin wounds and the mechanisms involved in this response. Sub-inhibitory concentrations of cinnamaldehyde reduced P. aeruginosa metabolic rate and its ability to form biofilm and to cause haemolysis. Daily topical application of cinnamaldehyde on P. aeruginosa-infected skin wounds reduced tissue bacterial load and promoted faster healing. Lower interleukin-17 (IL-17), vascular endothelial growth factor (VEGF) and nitric oxide levels were detected in cinnamaldehyde-treated wound samples. Blockage of transient receptor potential ankyrin 1, the pharmacological target of cinnamaldehyde, abrogated its healing activity and partially reversed the inhibitory actions of this compound on VEGF and IL-17 generation. We suggest that topical application of sub-inhibitory concentrations of cinnamaldehyde may represent an interesting approach to improve the healing of P. aeruginosa-infected skin wounds. |
| Databáze: | OpenAIRE |
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