Free Radicals Scavenging Efficiency of a Few Naturally Occurring Flavonoids: A Comparative Study
| Autor: | P. Manisankar, Muthia Rajendran, Ramachandran Murugesan, R. Gandhidasan |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Radical
Morin Medicinal chemistry Antioxidants Lipid peroxidation Structure-Activity Relationship chemistry.chemical_compound Superoxides Organic chemistry heterocyclic compounds Benzothiazoles Flavonoids ABTS Free Radical Scavengers General Chemistry Mannose-Binding Lectins chemistry Radical ion Arachidonic acid Lipid Peroxidation Trolox Plant Lectins Sulfonic Acids General Agricultural and Biological Sciences Quercetin DNA Damage |
| Zdroj: | Journal of Agricultural and Food Chemistry. 52:7389-7394 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/jf0400718 |
| Popis: | The interaction of antiperoxidative flavonoids artocarpin (AR), cycloartocarpin (CAR), dalspinin (DP), dalspinosin (DPO), and dalspinin-7-O-galactoside (DPG) with 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS(.+)) and O2(-.) was studied in phosphate buffer (pH 7.4). The ability of these compounds to inhibit lipid peroxidation and DNA scission was also investigated. The radical scavenging efficiency of flavonoids is demonstrated by the reduction of nitrogen-centered radical cation (ABTS(.+)). The reduction of ABTS(.+) follows the order quercetin > morin > Trolox > AR > DPO > CAR > DP. Inhibition of lipid peroxidation was studied by following Mb(IV) reduction, induced by lipid, arachidonic acid. These results are compared with those obtained for well-known antioxidants such as quercetin, morin, and Trolox. The structure-activity relationships between chemical structures of the flavonoids and their radical scavenging activities are anlayzed. The scavenging of O2(-.), inhibition of lipid peroxidation, and DNA damage depend on the oxidation potential of the flavonoids. The possible mechanism for radical scavenging activities of flavonoids in relation to their structure is also outlined. |
| Databáze: | OpenAIRE |
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