Reduction of the Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Mice Using an Antiulcer Drug, Geranylgeranylacetone
| Autor: | Akifumi Akamine, Junpei Mutoh, Yuji Ishii, Takumi Ishida, Hideyuki Yamada, Isao Hashiguchi, Tomomi Oshimo, Kazuta Oguri, Akihisa Nishimura, Nobuyuki Koga |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Polychlorinated Dibenzodioxins Time Factors Antiulcer drug Gene Expression Pharmaceutical Science Kidney Mice Pregnancy Internal medicine medicine Animals HSP70 Heat-Shock Proteins heterocyclic compounds Pharmacology Fetus Chemistry Body Weight Abnormalities Drug-Induced Organ Size General Medicine Anti-Ulcer Agents Molecular medicine Acute toxicity Tetrachlorodibenzo-p-dioxin Mice Inbred C57BL Endocrinology Mrna level Toxicity Female Diterpenes Receptor activation |
| Zdroj: | Biological and Pharmaceutical Bulletin. 27:1397-1402 |
| ISSN: | 1347-5215 0918-6158 |
| Popis: | The protective effect of geranylgeranylacetone (GGA), an antiulcer drug, against the acute toxicity and teratogenicity produced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was examined in C57BL/6J mice. When mice were co-treated, GGA reduced the loss of body weight gain and lethality produced by TCDD but hepatomegaly and thymic atrophy were not improved. Additionally, no protective effect of GGA was observed in the formation of cleft palate and hydronephrosis in mouse fetuses caused by maternal exposure to TCDD. To clarify the reducing mechanism by GGA, the Hsp70.1 mRNA levels in liver and intestine were analyzed. However, it was difficult to explain the effect of GGA from the induction of Hsp70.1. GGA had also no effect on the induction of hepatic ethoxyresorufin O-deethylase activity by TCDD. These data suggest that GGA exhibits a protective effect against some forms of dioxin toxicity by a mechanism without involving inhibition of arylhydrocarbon receptor activation. |
| Databáze: | OpenAIRE |
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