Inhibition of growth of human breast carcinoma xenografts by energy expenditure via voluntary exercise in athymic mice fed a high-fat diet
| Autor: | Margaret A. Welsch, Clifford W. Welsch, Leonard A. Cohen |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Cancer Research
medicine.medical_specialty Ratón Mammary gland Physical Exertion Transplantation Heterologous Medicine (miscellaneous) Mice Nude Physical exercise Mice Internal medicine medicine Carcinoma Animals Humans Nutrition and Dietetics Epithelioma business.industry Mammary Neoplasms Experimental medicine.disease Dietary Fats Transplantation Endocrinology medicine.anatomical_structure Oncology Energy expenditure Turnover Female business Energy Metabolism Food Deprivation Neoplasm Transplantation |
| Zdroj: | Nutrition and cancer. 23(3) |
| ISSN: | 0163-5581 |
| Popis: | The purpose of this study was to assess the effect of energy expenditure, via voluntary exercise, on growth of xenografts of human breast carcinomas in athymic nude mice. Sedentary and exercising athymic nude mice bearing subcutaneous grafts of MDA-MB231 human breast carcinomas were fed daily a purified high-fat diet at 10% less than ad libitum to ensure an equal quantity of diet (energy) consumption for each sedentary and exercising mouse. The sedentary and exercising mice were housed singly; the exercising mice had, in addition, access to an activity wheel (24 hrs/day). Growth of human breast carcinomas (carcinoma volumes) was evaluated during a five-week periods. Mean running activities of individual mice over the five-week period ranged from1 to 7.9 miles/day. Growth of the human breast carcinomas was significantly inversely correlated with the mean number of miles that each mouse ran per day (p0.018). Upon separation of these mice into two running groups, i.e., those that averaged 2.7-4.7 miles/day and those that averaged4.7 miles/day, carcinoma growth was 83% of sedentary controls in the former group (p = 0.305) and 59% of sedentary controls in the latter group (p = 0.039). These results provide evidence that energy expenditure, via voluntary use of an activity wheel, can reduce significantly the growth of human breast carcinomas maintained in athymic nude mice. |
| Databáze: | OpenAIRE |
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