An Investigation of Japanese Neonatal and Maternal Antibody Status against Pertussis
| Autor: | Yuto Fukuda, Mako Hasegawa, Ayami Yoshikane, Naoko Nishimura, Kensei Gotoh, Tomoyasu Noguchi, Takuto Ito, Takuya Akano, Hiroki Takao, Shuta Kito, Koji Takemoto, Takao Ozaki |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Whooping Cough 030106 microbiology Physiology Mothers Gestational Age Pertussis toxin Immunoglobulin G 03 medical and health sciences Young Adult 0302 clinical medicine Japan Pregnancy Seroepidemiologic Studies Seroprevalence Medicine Humans 030212 general & internal medicine biology business.industry Vaccination Infant Newborn Gestational age General Medicine Middle Aged Antibodies Bacterial Titer Infectious Diseases Maternal antibody Pertussis Toxin biology.protein Female Antibody business Immunity Maternally-Acquired |
| Zdroj: | Japanese journal of infectious diseases. 73(3) |
| ISSN: | 1884-2836 |
| Popis: | To clarify the pertussis immune status of the Japanese population, we investigated levels of serum pertussis toxin (PT)-specific immunoglobulin G (IgG) antibody in infants and mothers between April 2016 and March 2018. A total of 206 infants (n = 22, < 32 weeks of gestational age [wGA]; n = 70, 32-36 wGA; n = 114, ≥ 37 wGA) and 170 mothers were enrolled. The maternal seroprevalence and antibody geometric mean titer (GMT) were 52.4% and 10.7 EU/mL, respectively. The antibody GMT, seroprevalence, and mean ratio of infant to maternal antibody titers of infants at < 32 wGA were 3.2 EU/mL, 13.6%, and 42.5%, respectively, and were significantly lower than those of infants at 32-36 wGA (9.7 EU/mL, 54.3%, and 110.2%) and infants at ≥ 37 wGA (12.1 EU/mL, 57.9%, and 112.6%). Of the 21 infants who underwent a second examination, five were positive in the first examination. Of those five, the GMT for PT had decreased by an average of 52.6% at 4.3- week intervals. In the second examination, two infants were seropositive. Approximately half of the mothers and infants were negative for anti-PT antibody. Thus, new vaccination strategies, such as the vaccination of pregnant women, are needed to prevent pertussis infection in early infancy. |
| Databáze: | OpenAIRE |
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