Analysis of clinical manifestations and treatment in 26 children with fibrodysplasia ossificans progressiva in China
| Autor: | Jianghong Deng, Weiying Kuang, Jiang Wang, Shuang-Ying Ke, Caifeng Li, Yurong Piao, Xiaohua Tan, Tongxin Han, Junmei Zhang, Chao Li |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Diagnostic Imaging
Male China Pediatrics medicine.medical_specialty Disease 03 medical and health sciences 0302 clinical medicine 030225 pediatrics Pediatric surgery Deformity medicine Humans 030212 general & internal medicine Child Glucocorticoids Retrospective Studies business.industry Anti-Inflammatory Agents Non-Steroidal Infant Newborn Infant Little finger Prognosis medicine.disease Connective tissue disease Clinical Practice medicine.anatomical_structure Myositis Ossificans Child Preschool Fibrodysplasia ossificans progressiva Pediatrics Perinatology and Child Health Female Active treatment medicine.symptom business Immunosuppressive Agents |
| Zdroj: | World Journal of Pediatrics. 16:82-88 |
| ISSN: | 1867-0687 1708-8569 |
| Popis: | Fibrodysplasia ossificans progressiva (FOP) is a rare and disabling heritable connective tissue disease that is difficult to treat. This study seeks to explore the clinical characteristics, clinical manifestations, treatment and prognosis of FOP to provide a clinical basis for its early diagnosis and treatment. Twenty-six children with FOP were retrospectively analyzed in terms of their onset, clinical manifestations, auxiliary examinations and treatment. Among the 26 cases, the youngest age of manifestation of mass was 8 days after birth, and the average age was 3 years and 2 months. The peak age was 2–5 years old. Inflammatory mass and toe-finger deformity are the main early clinical manifestations of the disease. These inflammatory masses often lead to hard osteogenic deposits that initially mainly involve the central axis, such as the neck (22/26, 84.6%), back (20/26, 76.9%), and head (13/26, 50%). Toe-finger deformity mainly manifests as symmetrical great toe deformity, or short and deformed thumb and little finger. The diagnosis of FOP requires typical clinical manifestations or ACVR1 gene detection. The main therapeutic drugs for FOP include glucocorticoids and non-steroidal anti-inflammatory drugs. Although not compliant with the recommended medical management of FOP, in our clinical practice children with uncontrollable illness could be treated using a variety of immunosuppressive agents in combination. FOP is a rare autosomal dominant heritable disease. The main clinical manifestations observed in this study were recurrent inflammatory mass and toe-finger deformity. If the diagnosis and treatment are not performed in a timely manner, serious complications are likely to affect the prognosis. Therefore, early diagnosis and active treatment should be performed. |
| Databáze: | OpenAIRE |
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