Insights into the post-transcriptional regulation of the mitochondrial electron transport chain
| Autor: | Tamara Sirey, Chris P. Ponting |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
RNA Mitochondrial eukaryotic gene expression Cellular homeostasis RNA-binding protein Biology DNA Mitochondrial Biochemistry Oxidative Phosphorylation Electron Transport 03 medical and health sciences mitochondrial respiration microRNA Gene expression Animals Humans Post-transcriptional regulation Regulation of gene expression Models Genetic RNA-Binding Proteins Mitochondria in Health and Disease Electron transport chain Mitochondria Cell biology 030104 developmental biology Gene Expression Regulation Metabolic regulation RNA metabolic regulation |
| Zdroj: | Sirey, T & Ponting, C 2016, ' Insights into the post-transcriptional regulation of the mitochondrial electron transport chain ', Biochemical Society Transactions . https://doi.org/10.1042/BST20160100 Biochemical Society Transactions |
| Popis: | The regulation of the mitochondrial electron transport chain is central to the control of cellular homeostasis. There are significant gaps in our understanding of how the expression of the mitochondrial and nuclear genome-encoded components of the electron transport chain are co-ordinated, and how the assembly of the protein complexes that constitute the electron transport chain are regulated. Furthermore, the role post-transcriptional gene regulation may play in modulating these processes needs to be clarified. This review summarizes the current knowledge regarding the post-transcriptional gene regulation of the electron transport chain and highlights how noncoding RNAs may contribute significantly both to complex electron transport chain regulatory networks and to mitochondrial dysfunction. |
| Databáze: | OpenAIRE |
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