The clinicopathologic significance of Tks5 expression of peritoneal mesothelial cells in gastric cancer patients

Autor: Gen Tsujio, Kazuya Muguruma, Atsushi Sugimoto, Shuhei Kushiyama, Mami Yoshii, Sadaaki Nishimura, Hiroaki Tanaka, Tomohiro Sera, Shingo Togano, Masakazu Yashiro, Tomohisa Okuno, Kenji Kuroda, Tatsuro Tamura, Masaichi Ohira, Koji Maruo, Yurie Yamamoto, Yuichiro Miki, Takahiro Toyokawa
Rok vydání: 2021
Předmět:
0301 basic medicine
Male
Skin Neoplasms
medicine.medical_treatment
Gastroenterology
Metastasis
Prostate cancer
0302 clinical medicine
Mathematical and Statistical Techniques
Basic Cancer Research
Breast Tumors
Abdomen
Medicine and Health Sciences
Skin Tumors
Peritoneal Neoplasms
Lesser omentum
Multidisciplinary
Invasive Tumors
Prostate Cancer
Statistics
Prostate Diseases
Greater omentum
Middle Aged
medicine.anatomical_structure
Oncology
030220 oncology & carcinogenesis
Lymphatic Metastasis
Physical Sciences
Immunohistochemistry
Medicine
Female
Peritoneum
Anatomy
Research Article
medicine.medical_specialty
Science
Urology
Dermatology
Research and Analysis Methods
Disease-Free Survival
03 medical and health sciences
Gastrectomy
Stomach Neoplasms
Internal medicine
Gastrointestinal Tumors
Breast Cancer
medicine
Biomarkers
Tumor
Humans
Neoplasm Invasiveness
Statistical Methods
Aged
business.industry
Cancer
Cancers and Neoplasms
Biology and Life Sciences
Epithelial Cells
medicine.disease
Adaptor Proteins
Vesicular Transport
Gastric Cancer
Genitourinary Tract Tumors
030104 developmental biology
Multivariate Analysis
business
Mathematics
Follow-Up Studies
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 7, p e0253702 (2021)
ISSN: 1932-6203
Popis: Background Gastric cancer (GC) patients frequently develop peritoneal metastasis. Recently, it has been reported that peritoneal mesothelial cells (PMCs) activated by GC cells acquire a migratory capacity and promote GC cell invasion. The invasiveness of PMCs reportedly depends on the activity of Tks5, an adaptor protein required for invadopodia formation. However, the relationship between clinicopathologic features and Tks5 expression in PMCs has been poorly documented. In this study, we evaluated the clinicopathologic significance of the Tks5 expression of PMCs in GC patients. Materials and methods A total of 110 GC patients who underwent gastrectomy were enrolled in this study. Tks5 expressions in PMCs from the greater omentum, lesser omentum and retroperitoneum were evaluated by immunohistochemistry. We analyzed the correlation between Tks5 expressions in PMCs and the patients’ clinicopathologic features. Results Tks5 expression was found in 71 (64.5%) of the 110 patients, while 39 (35.5%) were Tks5-negative. Tks5 positivity was significantly (p = 0.038) associated with a greater tumor depth (i.e., T3/4 compared with T1/T2). Peritoneal recurrence was found in 12 of 98 cases within 3 years of surgery. The 3-year peritoneal recurrence-free survival (PRFS) rate in Tks5-positive cases was significantly poorer than that in Tks5-negative cases (80.1% vs 97.4%, p = 0.024). Multivariate analysis revealed that Tks5 positivity and lymph node metastasis were independent factors for PRFS. Conclusion Tks5 is frequently expressed in PMCs in advanced-stage gastric cancer. Tks5 might be a useful predictor for peritoneal recurrence in GC patients.
Databáze: OpenAIRE
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