Mapping antigenic diversity and strain specificity of mumps virus: A bioinformatics approach
| Autor: | Rajeev M. Dhere, G. Sunitha Manjari, Deepti D. Deobagkar, Subhash V. Kapre, Asha D. Mallya, Urmila Kulkarni-Kale, Janaki Ojha |
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| Rok vydání: | 2007 |
| Předmět: |
Models
Molecular Genetic Speciation Protein Conformation Bioinformatics HN Mumps virus Biology Sequential epitope medicine.disease_cause Epitope Viral Proteins Antigenic Diversity Species Specificity Antigen Virology medicine HN Protein Antigens Viral Hemagglutinin–neuraminidase Homology model Wild and vaccine strain Computational Biology Molecular immunology Antigenic Variation Vaccination Conformational epitope Hemagglutinin-neuraminidase |
| Zdroj: | Virology. 359(2):436-446 |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2006.09.040 |
| Popis: | Mumps is an acute infectious disease caused by mumps virus, a member of the family Paramyxoviridae. With the implementation of vaccination programs, mumps infection is under control. However, due to resurgence of mumps epidemics, there is a renewed interest in understanding the antigenic diversity of mumps virus. Hemagglutinin–neuraminidase (HN) is the major surface antigen and is known to elicit neutralizing antibodies. Mutational analysis of HN of wild-type and vaccine strains revealed that the hypervariable positions are distributed over the entire length with no detectable pattern. In the absence of experimentally derived 3D structure data, the structure of HN protein of mumps virus was predicted using homology modeling. Mutations mapped on the predicted structures were found to cluster on one of the surfaces. A predicted conformational epitope encompasses experimentally characterized epitopes suggesting that it is a major site for neutralization. These analyses provide rationale for strain specificity, antigenic diversity and varying efficacy of mumps vaccines. |
| Databáze: | OpenAIRE |
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