Recurrent renal cell carcinoma: clinical and prognostic value of FDG PET/CT
| Autor: | Laura Evangelista, Giorgio Saladini, Fabio Zattoni, Maria Picchio, Luigi Gianolli, Pierpalolo Alongi, Marianna Spallino |
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| Přispěvatelé: | Alongi, Pierpaolo, Picchio, Maria, Zattoni, Fabio, Spallino, Marianna, Gianolli, Luigi, Saladini, Giorgio, Evangelista, Laura |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Radiology Nuclear Medicine and Imaging Computed tomography Recurrent renal cell carcinoma Kaplan-Meier Estimate Multimodal Imaging 030218 nuclear medicine & medical imaging 0302 clinical medicine Renal cell carcinoma Recurrence Retrospective Studie Nuclear Medicine and Imaging medicine.diagnostic_test Kidney Neoplasm General Medicine Middle Aged Prognosis Kidney Neoplasms Treatment Outcome Positron emission tomography 030220 oncology & carcinogenesis Disease Progression Radiopharmaceutical Fdg pet ct Female Radiology Human medicine.medical_specialty Prognosi Decision Making Sensitivity and Specificity 03 medical and health sciences Fluorodeoxyglucose F18 medicine Humans Radiology Nuclear Medicine and imaging neoplasms Carcinoma Renal Cell Proportional Hazards Models Retrospective Studies Aged Neoplasm Staging business.industry FDG PET/CT Multivariate analysis Multivariate analysi medicine.disease Decision Support Systems Clinical carbohydrates (lipids) Positron-Emission Tomography Proportional Hazards Model Radiopharmaceuticals Neoplasm Recurrence Local Nuclear medicine business Tomography X-Ray Computed |
| Popis: | Purpose: The purpose of our study was 1) to evaluate the diagnostic performance of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT), 2) to assess the impact of FDG PET/CT on treatment decision-making, and 3) to estimate the prognostic value of FDG PET/CT in the restaging process among patients with renal cell carcinoma (RCC). Methods: From the FDG PET/CT databases of San Raffaele Hospital in Milan, Italy, and the Veneto Institute of Oncology in Padua, Italy, we selected 104 patients with a certain diagnosis of RCC after surgery, and for whom at least 24 months of post-surgical FDG PET/CT, clinical, and instrumental follow-up data was available. The sensitivity and specificity of FDG PET/CT were assessed by histology and/or other imaging as standard of reference. Progression-free survival (PFS) and overall survival (OS) were computed using the KaplanâMeier method. Univariate and multivariate Cox proportional hazards models were used to identify predictors of outcome. Results: FDG PET/CT resulted in a positive diagnosis in 58 patients and a negative diagnosis in 46 patients. Sensitivity and specificity were 74 % and 80 %, respectively. FDG PET/CT findings influenced therapeutic management in 45/104 cases (43 %). After a median follow-up period of 37 months (± standard deviation 12.9), 51 (49 %) patients had recurrence of disease, and 26 (25 %) had died. In analysis of OS, positive versus negative FDG PET/CT was associated with worse cumulative survival rates over a 5-year period (19 % vs. 69 %, respectively; p |
| Databáze: | OpenAIRE |
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