Longitudinal diffusion tensor imaging of the rat brain after hexachlorophene exposure
| Autor: | Merle G. Paule, Tetyana Konak, Joseph P. Hanig, Jaivijay Ramu, Serguei Liachenko |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Time Factors Hexachlorophene Toxicology Nerve Fibers Myelinated White matter Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Nuclear magnetic resonance In vivo Fractional anisotropy medicine Image Processing Computer-Assisted Effective diffusion coefficient Animals Longitudinal Studies Anisotropy business.industry Chemistry General Neuroscience Neurotoxicity Brain medicine.disease White Matter Rats 030104 developmental biology medicine.anatomical_structure Diffusion Tensor Imaging Anti-Infective Agents Local Nuclear medicine business 030217 neurology & neurosurgery Diffusion MRI medicine.drug |
| Zdroj: | Neurotoxicology. 56 |
| ISSN: | 1872-9711 |
| Popis: | Longitudinal MRI employing diffusion tensor imaging and T2 mapping approaches has been applied to investigate the mechanisms of white matter damage caused by acute hexachlorophene neurotoxicity in rats in vivo. Male Sprague-Dawley rats were administered hexachlorophene orally once a day for five consecutive days at a dose of 30mg/kg and were monitored in 7T MRI scanner at days 0 (baseline), 3, 6, 13, and 20 following the first hexachlorophene dose. Quantitative T2 maps as well as a number of diffusion tensor parameters (fractional anisotropy, radial and axial diffusivity, apparent diffusion coefficient, and trace) were calculated from corresponding MR images. T2, as well as all diffusion tensor derived parameters (except fractional anisotropy) showed significant changes during the course of neurotoxicity development. These changes peaked at 6days after the first dose of hexachlorophene (one day after the last dose) and recovered to practically baseline levels at the end of observation (20days from the first dose). While such changes in diffusivity and T2 relaxation clearly demonstrate myelin perturbations consistent with edema, the lack of changes of fractional anisotropy suggests that the structure of the myelin sheath was not disrupted significantly by hexachlorophene in this study. This is also confirmed by the rapid recovery of all observed MRI parameters after cessation of hexachlorophene exposure. |
| Databáze: | OpenAIRE |
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