Application of Volumetric Modulated Arc Therapy and Simultaneous Integrated Boost Techniques to Prepare 'Safe Margin' in the Rabbit VX2 Limb Tumor Model
| Autor: | Guang-Li Shi, Jiao-Jiao Ding, Jing-Ping Bai, Chong-Wen Wang, Dong-Hui Ma, Hao Liu, Yang Zhou, Wenting Li, Peng-Ming Xie, Yue Yan, Yan Liu |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Simultaneous integrated boost medicine.medical_specialty medicine.medical_treatment Soft Tissue Neoplasms Necrosis Imaging Three-Dimensional Margin (machine learning) medicine Animals Effective diffusion coefficient medicine.diagnostic_test business.industry Animal Study Histological Techniques Angiography Ultrasonography Doppler Extremities Radiotherapy Dosage Magnetic resonance imaging Rabbit (nuclear engineering) General Medicine medicine.disease Magnetic Resonance Imaging Radiation therapy Diffusion Magnetic Resonance Imaging Rabbits Radiotherapy Intensity-Modulated Sarcoma Experimental Radiology Sarcoma business |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| DOI: | 10.12659/msm.894909 |
| Popis: | Background In this study, we aimed to establish the rabbit VX2 limb tumor model, and then prepare a "necrotic zone" as a safe margin by volumetric modulated arc therapy and simultaneous integrated boost (VMAT-SIB) technique applied in the areas where the tumor is located adjacent to the bone (GTVboost area). Material and methods Rabbits in the control group (n=10) were not treated, while those in the test group (n=10) were treated with the SIB schedule delivering a dose of 40Gy, 35Gy, 30Gy, and 25Gy to the GTVboost, GTV (gross tumor volume), CTV (clinical target volume), and PTV (planning target volume) in 10 fractions. Magnetic resonance diffusion-weighted imaging (MRDWI), 3-dimensional power Doppler angiography (3D-PDA), and histological changes were observed after radiotherapy. Results After radiotherapy, the two groups showed a significant difference in the GTVboost area. In the test group, the tumor necrosis showed a significantly low signal in DWI and high signal in apparent diffusion coefficient (ADC) maps. The 3D-PDA observation showed that tumor vascular structures decreased significantly. Histological analysis demonstrated that a necrotic zone could be generated in the GTVboost area, and microscopic examination observed cell necrosis and fibroplasia. Conclusions This studies demonstrated the feasibility of using VMAT-SIB technique in the rabbit VX2 limb tumor model. The formation of a necrotic zone can be effectively defined as safe margin in the GTVboost area. showing potential clinical applicability. |
| Databáze: | OpenAIRE |
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