| Autor: |
Vincent Morizur, Rosa Nechak, Sophie Poulain Martini, Bellara Nedjar Kolli, Lydia Salhi, Elisabet Duñach, Yamina Benmalek, Samia Bouzroura |
| Rok vydání: |
2014 |
| Předmět: |
|
| DOI: |
10.6084/m9.figshare.1194996 |
| Popis: |
Series of thiosemicarbazones 3a-d and 4-thiazolidinones 5a-d, 7a-d and 9a-h were synthesized and evaluated for their in vitro antimicrobial activity. Condensation of 3-acetyl-4-hydroxy-6-methyl-2H pyran-2-one1 (dehydroacetic acid) with thiosemicarbazide 2a-d in ethanol at room temperature yielded the thiosemicarbazones 3a-d. These compounds were exploited to synthesize the 4-thiazolidinones 5a-d via their reactions with ethyl 2-bromo propionate4. Derivatives 7a-d were prepared by reaction of the thiosemicarbazones 3a-d with phenyl bromoacetate 6. The 4-thiazolidinones 9a-h were obtained by treatment of compound 3a or 3c with maleimide derivatives 8a-d in refluxing ethanol, under sulphuric acid catalysis. All compounds were screened in vitro for their antibacterial and antifungal activities against five human pathogens micro organisms: Escherichia coli ATCC 25992, Pseudomonas aeruginosa ATCC 27852, Staphylococcus aureus ATCC 43300, Staphylococcus aureus ATCC 25923and Candida albicans. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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