Switching antidepressant class does not improve response or remission in treatment-resistant depression
| Autor: | Joseph Zohar, Raffaella Calati, Sylvie Linotte, Pierre Oswald, Isabelle Massat, Stuart Montgomery, Joseph Bollen, Koen Demyttenaere, Siegfried Kasper, Daniel Souery, Yves Lecrubier, Anastasios Konstantinidis, Alessandro Serretti, Julien Mendlewicz |
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| Přispěvatelé: | Souery, D, Serretti, A, Calati, R, Oswald, P, Massat, I, Konstantinidis, A, Linotte, S, Bollen, J, Demyttenaere, K, Kasper, S, Lecrubier, Y, Montgomery, S, Zohar, J, Mendlewicz, J, Souery D., Serretti A., Calati R., Oswald P., Massat I., Konstantinidis A., Linotte S., Bollen J., Demyttenaere K., Kasper S., Lecrubier Y., Montgomery S., Zohar J., Mendlewicz J. |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Psychotherapist pharmacotherapy Young Adult remission Pharmacotherapy medicine Humans Pharmacology (medical) Psychiatry Depression (differential diagnoses) Aged Retrospective Studies Aged 80 and over Class (computer programming) Depressive Disorder Major response antidepressant resistant depression Drug Substitution Remission Induction Retrospective cohort study Middle Aged medicine.disease Antidepressive Agents Psychiatry and Mental health Treatment Outcome treatment-resistant depression Antidepressant Female Psychology major depression Treatment-resistant depression |
| Zdroj: | Journal of clinical psychopharmacology. 31(4) |
| ISSN: | 1533-712X |
| Popis: | Objective: The management of treatment-resistant depression is a much debated issue. In particular, the evidence supporting the commonly suggested sequential use of antidepressants from 2 different pharmacological classes is weak.This retrospective study was undertaken to investigate whether there is a better response in nonresponders switched to a different class of antidepressants (across-class) compared with nonresponders switched to an antidepressant from the same class (within-class). Methods: Three hundred forty patients with primary major depressive disorder were recruited in the context of a European multicenter project. Subjects whose current depressive episode had failed to respond to a first antidepressant trial of adequate dose and duration were included. Results: There was no significant difference in response or remission rates between the across-class and within-class groups after controlling for possible confounders. Conclusions: In depressed nonresponders to a previous antidepressant treatment, switching to a different class of antidepressants was not associated with a better response or remission rate. © 2011 Lippincott Williams & Wilkins. |
| Databáze: | OpenAIRE |
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