Cerebrospinal fluid biomarkers in Alzheimer's disease, vascular dementia and ischemic stroke patients: a critical analysis
| Autor: | Katharina Stoeck, Inga Zerr, Andre Kuhlmann, Lisa Kaerst, Dirk Wedekind, Peter Lange |
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| Rok vydání: | 2013 |
| Předmět: |
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medicine.medical_specialty Pathology Neurology Aß Clinical Neurology Context (language use) tau Proteins CSF Vascular dementia Brain Ischemia Brain ischemia 03 medical and health sciences 0302 clinical medicine Biomarkers Tau Alzheimer’s disease Stroke Alzheimer Disease Internal medicine mental disorders medicine Dementia Humans Cognitive Dysfunction cardiovascular diseases 030304 developmental biology Neuroradiology Aged Aged 80 and over 0303 health sciences Amyloid beta-Peptides Original Communication business.industry Dementia Vascular Middle Aged medicine.disease Peptide Fragments Medicine & Public Health Neurosciences Cardiology Female Neurology (clinical) Alzheimer's disease business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neurology |
| ISSN: | 1432-1459 |
| Popis: | Vascular factors are thought to contribute to the development of disease pathology in neurodegenerative dementia such as Alzheimer’s disease (AD). Another entity, called vascular dementia (VaD), comprises a less defined group of dementia patients having various vascular diseases that especially emerge in the elderly population and require valid options for examination and differential diagnosis. In the context of a retrospective study, we analyzed the cerebrospinal fluid (CSF) biomarkers t-tau, p-tau and Aß42 of a total of 131 patients with AD (n = 47), mild cognitive impairment (MCI) (n = 22), VaD (n = 44) and stroke (n = 18). We found a remarkable alteration in CSF biomarker profile in AD, VaD and in acute ischemic events. CSF profile in AD patients was altered in a very similar way as in stroke patients, without statistical differences. In stroke, increase depend largely on size and duration after the initial event. Total tau levels were useful to differ between VaD and stroke. Aß42 decreased in a similar way in AD, VaD and stroke and had a trend to lower levels in MCI but not in controls. peerReviewed |
| Databáze: | OpenAIRE |
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