Elevated Mucosal Addressin Cell Adhesion Molecule–1 Expression in Acquired Immunodeficiency Syndrome Is Maintained during Antiretroviral Therapy by Intestinal Pathogens and Coincides with Increased Duodenal CD4 T Cell Densities
Autor: | Peter Hayes, Brian Gazzard, Yin M. Miao, Frances Gotch, M. C. Barrett, Nicholas Francis |
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Rok vydání: | 2002 |
Předmět: |
Male
Duodenum Opportunistic infection T-Lymphocytes Lymphocyte Immunoglobulins Biology Lymphocyte Activation Virus Mucoproteins Antiretroviral Therapy Highly Active medicine Addressin Humans Immunology and Allergy Acquired Immunodeficiency Syndrome Lamina propria Cell adhesion molecule virus diseases Mucous membrane T lymphocyte Middle Aged Viral Load Flow Cytometry medicine.disease Immunohistochemistry CD4 Lymphocyte Count Intestines Infectious Diseases medicine.anatomical_structure Immunology biology.protein Female Cell Adhesion Molecules |
Zdroj: | The Journal of Infectious Diseases. 185:1043-1050 |
ISSN: | 1537-6613 0022-1899 |
DOI: | 10.1086/340235 |
Popis: | Reduced intestinal CD4 T cell numbers and gastrointestinal disease are common features of acquired immunodeficiency syndrome (AIDS). Duodenal lymphocyte densities and mucosal addressin cell adhesion molecule (MAdCAM)-1 expression were analyzed in patients with AIDS after highly active antiretroviral therapy (HAART). Compared with human immunodeficiency virus (HIV)-seronegative individuals, HAART-naive patients with AIDS displayed reduced duodenal CD4 T cell densities. After HAART, AIDS patients with opportunistic intestinal pathogens displayed greater increases in duodenal lamina propria (LP) CD4 T cell densities than patients without such infections. Duodenal MAdCAM-1 expression was elevated in all HAART-naive patients with AIDS but remained elevated only in the intestinal pathogen group after HAART. The data suggest that, in HIV-1 infection, lymphocyte migration to the intestine may be promoted by increased MAdCAM-1 expression. After HAART, opportunistic intestinal pathogens maintain elevated MAdCAM-1 expression, which results in prominent increases in LP CD4 T cell densities in the absence of HIV-mediated CD4 T cell destruction. |
Databáze: | OpenAIRE |
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