Loss of expression of DNA repair enzyme MGMT in oral leukoplakia and early oral squamous cell carcinoma. A prognostic tool?
| Autor: | María Rodríguez, María Teresa Ruesga, José M. Aguirre, J. M. Rivera, Amelia Acha, Carlos Larrinaga Rodríguez |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Time Factors DNA repair Cell Kaplan-Meier Estimate medicine.disease_cause O(6)-Methylguanine-DNA Methyltransferase Internal medicine Oral and maxillofacial pathology Carcinoma Humans Medicine neoplasms Carcinogen Leukoplakia Chi-Square Distribution business.industry Smoking Middle Aged Prognosis medicine.disease Immunohistochemistry digestive system diseases stomatognathic diseases medicine.anatomical_structure Carcinoma Squamous Cell Female Mouth Neoplasms Leukoplakia Oral business Carcinogenesis |
| Zdroj: | Cancer Letters. 245:263-268 |
| ISSN: | 0304-3835 |
| Popis: | MGMT is a specific DNA repair enzyme that removes alkylating lesions and therefore plays an important role in maintaining normal cell physiology and genomic stability. Loss of expression of MGMT is associated with increased carcinogenic risk and sensitivity to methylating agents in different types of tumours. The expression of MGMT was immunohistochemically assessed in 12 normal oral mucosa, 38 oral leukoplakias and 33 early oral squamous cell carcinomas. The results were correlated with clinicopathological data. We found a significant loss of MGMT protein expression from leukoplakia when compared with early squamous cell carcinoma. We also observed a statistically significant relationship between smoking and the loss of MGMT protein expression. Loss of MGMT expression could be considered an early event in oral carcinogenesis with possible prognostic implications. |
| Databáze: | OpenAIRE |
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