Evaluation of Retinal Structure and Optic Nerve Function Changes in Multiple Sclerosis: Longitudinal Study with 1-Year Follow-Up
Autor: | Darma Imran, Reza Aditya Arpandy, M. Sidik, David Pangeran, Kartika Maharani, Riwanti Estiasari, Saraf Shafa Marwadhani, Manfaluthy Hakim, Freddy Sitorus, Ni Nengah Rida Ariarini, Adisresti Diwyacitta |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Visual acuity Article Subject genetic structures media_common.quotation_subject Central nervous system 03 medical and health sciences 0302 clinical medicine Ophthalmology medicine Contrast (vision) Optic neuritis Prospective cohort study RC346-429 media_common medicine.diagnostic_test business.industry Multiple sclerosis Fundus photography medicine.disease eye diseases medicine.anatomical_structure Neurology 030221 ophthalmology & optometry Optic nerve Neurology (clinical) sense organs Neurology. Diseases of the nervous system medicine.symptom business 030217 neurology & neurosurgery Research Article |
Zdroj: | Neurology Research International, Vol 2021 (2021) Neurology Research International |
ISSN: | 2090-1860 2090-1852 |
Popis: | Background. Multiple sclerosis (MS) is an autoimmune disease characterized by inflammation and demyelination of the central nervous system which often involves the optic nerve even though only 20% of the patients experience optic neuritis (ON). Objective. This study aims to compare the retinal structure and optic nerve function between patients with MS and healthy controls (HCs), evaluate optic nerve alterations in MS over 1-year follow-up, and analyze its correlations with disease duration, number of relapses, degree of disability, and different subtypes. Methods. This is a prospective cohort study involving 58 eyes of MS patients. Optic nerve function was evaluated with best-corrected visual acuity (BCVA), contrast sensitivity, and P100 latency, while the retinal structure was evaluated from the GCIPL and RNFL thickness measured with optical coherence tomography (OCT) and fundus photography. Results. The MS group had lower BCVA ( p = 0.001 ), contrast sensitivity ( p < 0.001 ), mean GCIPL thickness ( p < 0.001 ), and mean RNFL thickness ( p < 0.001 ) than HC. At 6 and 12 months of observations, GCIPL and RNFL (nasal quadrant) of MS patients decreased significantly ( p = 0.007 and p = 0.004 , respectively). Disease duration and the number of relapses correlated with delayed P100 latency (r = −0.61, p < 0.001 and r = −0.46, p = 0.02 ). GCIPL and RNFL in the SPMS subtype were thinner than in RRMS. Conclusions. The retinal structure and optic nerve function of MS patients are worse than those of normal individuals. GCIPL and RNFL thinning occurs at 6 and 12 months but do not correlate with disease duration, the number of relapses, and degree of disability. |
Databáze: | OpenAIRE |
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