Repeatability and reproducibility of longitudinal relaxation rate in 12 small-animal MRI systems

Autor: Gunnar Schütz, Lars E. Olsson, Irvin Teh, Steven Sourbron, Andor Veltien, Jürgen E. Schneider, Michael Gottschalk, Iina Laitinen, William Lloyd, James P B O'Connor, Denise Steinmann, Hans Paul Juretschke, Catherine D. G. Hines, Sabina Ziemian, Xiaomeng Zhang, Simon Campbell, Sirisha Tadimalla, Claudia Green, Katja Hassemer, Kashmira Pindoria, John C. Waterton, Yanping Luo, Paul D. Hockings, Irma Mahmutovic Persson, Michael V. Haase, Klaus Strobel, Sascha Koehler
Jazyk: angličtina
Rok vydání: 2019
Předmět:
ResearchInstitutes_Networks_Beacons/MICRA
Materials science
Phantom
Biomedical Engineering
Biophysics
Saturation recovery
Longitudinal Relaxation Rate
Imaging phantom
Article
030218 nuclear medicine & medical imaging
03 medical and health sciences
Mice
All institutes and research themes of the Radboud University Medical Center
0302 clinical medicine
Nickel
Small animal
Urological cancers Radboud Institute for Molecular Life Sciences [Radboudumc 15]
medicine
Image Processing
Computer-Assisted
Water proton
Animals
Radiology
Nuclear Medicine and imaging
Computer Simulation
Hardware stability
Reproducibility
medicine.diagnostic_test
Phantoms
Imaging
Sepharose
Reproducibility of Results
Water
Relaxation time
Magnetic resonance imaging
Biomarker
Repeatability
Magnetic Resonance Imaging
Rats
Oxygen
Error propagation
Manchester Institute for Collaborative Research on Ageing
Regression Analysis
Protons
030217 neurology & neurosurgery
Biomarkers
MRI
Biomedical engineering
Zdroj: Magnetic Resonance Imaging
Magnetic Resonance Imaging, 59, 121-129
Magnetic Resonance Imaging, 59, pp. 121-129
Waterton, J C, Hines, C D G, Hockings, P D, Laitinen, I, Ziemian, S, Campbell, S, Gottschalk, M, Green, C, Haase, M, Hassemer, K, Juretschke, H P, Koehler, S, Lloyd, W, Luo, Y, Mahmutovic Persson, I, O'Connor, J P B, Olsson, L E, Pindoria, K, Schneider, J E, Sourbron, S, Steinmann, D, Strobel, K, Tadimalla, S, Teh, I, Veltien, A, Zhang, X & Schütz, G 2019, ' Repeatability and reproducibility of longitudinal relaxation rate in 12 small-animal MRI systems ', Magnetic Resonance Imaging, vol. 59, pp. 121-129 . https://doi.org/10.1016/j.mri.2019.03.008
ISSN: 0730-725X
Popis: Background: Many translational MR biomarkers derive from measurements of the water proton longitudinal relaxation rate R 1 , but evidence for between-site reproducibility of R 1 in small-animal MRI is lacking. Objective: To assess R 1 repeatability and multi-site reproducibility in phantoms for preclinical MRI. Methods: R 1 was measured by saturation recovery in 2% agarose phantoms with five nickel chloride concentrations in 12 magnets at 5 field strengths in 11 centres on two different occasions within 1–13 days. R 1 was analysed in three different regions of interest, giving 360 measurements in total. Root-mean-square repeatability and reproducibility coefficients of variation (CoV) were calculated. Propagation of reproducibility errors into 21 translational MR measurements and biomarkers was estimated. Relaxivities were calculated. Dynamic signal stability was also measured. Results: CoV for day-to-day repeatability (N = 180 regions of interest) was 2.34% and for between-centre reproducibility (N = 9 centres) was 1.43%. Mostly, these do not propagate to biologically significant between-centre error, although a few R 1 -based MR biomarkers were found to be quite sensitive even to such small errors in R 1 , notably in myocardial fibrosis, in white matter, and in oxygen-enhanced MRI. The relaxivity of aqueous Ni 2+ in 2% agarose varied between 0.66 s −1 mM −1 at 3 T and 0.94 s −1 mM −1 at 11.7T. Interpretation: While several factors affect the reproducibility of R 1 -based MR biomarkers measured preclinically, between-centre propagation of errors arising from intrinsic equipment irreproducibility should in most cases be small. However, in a few specific cases exceptional efforts might be required to ensure R 1 -reproducibility.
Databáze: OpenAIRE
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