Fall-risk increasing drugs and prevalence of polypharmacy in older patients discharged from an Orthogeriatric Unit after a hip fracture
| Autor: | Eva Delgado-Silveira, Sagrario Martín-Aragón, Aurora M. Rojo-Sanchís, Andrea Correa-Pérez, Alfonso J. Cruz-Jentoft |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Aging medicine.medical_specialty Drug-Related Side Effects and Adverse Reactions Population Poison control Angiotensin-Converting Enzyme Inhibitors Cohort Studies 03 medical and health sciences 0302 clinical medicine Older patients Risk Factors Injury prevention Activities of Daily Living Prevalence Medicine Humans 030212 general & internal medicine Accidental fall Practice Patterns Physicians' education Aged Retrospective Studies Polypharmacy Aged 80 and over education.field_of_study Hip fracture business.industry Hip Fractures Retrospective cohort study medicine.disease Patient Discharge Anti-Anxiety Agents Emergency medicine Accidental Falls Female Geriatrics and Gerontology business 030217 neurology & neurosurgery |
| Zdroj: | Aging clinical and experimental research. 31(7) |
| ISSN: | 1720-8319 |
| Popis: | Polypharmacy and fall-risk increasing drugs (FRIDS) have been associated with injurious falls. We aimed to estimate the prevalence of polypharmacy and FRIDS in older patients discharged from an Orthogeriatric Unit after a hip fracture surgery.This study describes the baseline findings of a 2-year retrospective cohort study. We included patients older than 80 years discharged from an Orthogeriatric Unit who were able to walk before surgery. Patient's baseline variables, total number of drugs, and FRIDS at hospital discharge were collected.We included 228 patients. The mean number of drugs and FRIDS prescribed at discharge was 11.6 ± 3.0 and 2.9 ± 1.6, respectively. Polypharmacy was prevalent in all patients except in three: 23.3% (5-9 drugs) and 75.9% (≥ 10 drugs). Only 11 patients had no FRIDS and 35.5% were on 3 FRIDS. The most prevalent FRIDS were: agents acting on the renin-angiotensin system (43.9%) and anxiolytics (39.9%). The number of FRIDS was higher in patients with extreme polypharmacy (3.4 ± 1.5) than in those on 5-9 drugs (1.5 ± 1.0, p 0.05). Independent people in performing instrumental activities had lower risk of extreme polypharmacy (≥ 10 drugs) or 3 FRIDS: OR 0.39 (95% CI 0.18-0.83) and OR 0.41 (95% CI 0.20-0.84), respectively. People living in a nursing home had higher risk of 3 FRIDS: OR 4.03 (95% CI 1.12-14.53).Polypharmacy and fall-risk increasing drugs are prevalent in patients discharged from orthogeriatric care after surgery for a hip fracture. Interventions on drug use at hospital discharge could have a potential impact on falls in this high-risk population. |
| Databáze: | OpenAIRE |
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