Alkenenitriles: Zn−Cu Promoted Conjugate Additions of Alkyl Iodides in Water
Autor: | Fraser F. Fleming, Subrahmanyam Gudipati |
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Rok vydání: | 2006 |
Předmět: | |
Zdroj: | Organic Letters. 8:1557-1559 |
ISSN: | 1523-7052 1523-7060 |
DOI: | 10.1021/ol060010q |
Popis: | [reaction: see text] A new silica-supported zinc-copper matrix dramatically promotes conjugate additions of alkyl iodides to alkenenitriles in water. Acyclic and cyclic nitriles react with functionalized alkyl iodides, overcoming the previous difficulty of performing conjugate additions to disubstituted alkenenitriles with nonstabilized carbon nucleophiles. Conjugate additions with omega-chloroalkyl iodides generate cyclic nitriles primed for cyclization, collectively providing one of the few annulation methods for cyclic alkenenitriles. |
Databáze: | OpenAIRE |
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