Nitric oxide levels in the aqueous humor in cataract patients
| Autor: | Ching Kuang Chou, Shih Hwa Chiou, Wen-Ming Hsu, Jung Chun Lin, Der Chong Tsai, Chih Chiau Wu, Chih Shun Wang, Chi Hsieh Peng, Chung Luen Kao, Chung Lan Kao, Jorn-Hon Liu, Charn Jung Chang |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Aging medicine.medical_specialty Adolescent genetic structures Eye disease Aqueous humor Nitric Oxide Cataract Nitric oxide Aqueous Humor Pathogenesis chemistry.chemical_compound Risk Factors Patient age Ophthalmology Humans Medicine No production Risk factor Child Aged Aged 80 and over Juvenile cataract business.industry Infant Middle Aged medicine.disease eye diseases Sensory Systems chemistry Child Preschool Surgery sense organs business |
| Zdroj: | Journal of Cataract and Refractive Surgery. 28:507-512 |
| ISSN: | 0886-3350 |
| Popis: | To determine the role of nitric oxide (NO) in the clinical manifestations of cataract in different age and etiological groups.Multicenter study, Taipei, Taiwan, Republic of China.Aqueous humor samples were obtained from 114 cataract patients in different etiological and age groups (eg, juvenile, traumatic, and age-related cataract). Using chemiluminescence assay, NO was detected through the light generated by ozone and NO interaction. The amount of NO production was calculated and compared among groups. The results were correlated with patient age.The NO levels in aqueous humor were highest in the 12 patients with traumatic cataract and lowest in the 15 patients with juvenile cataract (47.59 micromol/L +/- 12.81 [SD] and 7.66 +/- 2.62 micromol/L, respectively; P.001). Aqueous humor NO levels were correlated with age and were highest in patients older than 80 years (mean 38.78 +/- 6.29 micromol/L) and in those with mature cataract (mean 40.15 +/- 6.15 micromol/L) (P.05).The NO levels in the aqueous humor increased with age and traumatic events. The results suggest that NO could be a risk factor in cataract formation. |
| Databáze: | OpenAIRE |
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