Influence of T cell receptor V alpha expression on Mlsa superantigen-specific T cell responses
| Autor: | Osami Kanagawa, Kyuhei Tomonari, Richard J. Hodes, Melanie S. Vacchio |
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| Rok vydání: | 1992 |
| Předmět: |
Mice
Inbred BALB C Receptors Antigen T-Cell alpha-beta T-Lymphocytes T cell Immunology T-cell receptor Alpha (ethology) Articles T lymphocyte Biology Lymphocyte Activation Molecular biology Minor Lymphocyte Stimulatory Antigens Mice medicine.anatomical_structure Antigen medicine Superantigen Animals Immunology and Allergy Beta (finance) CD8 |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.175.5.1405 |
| Popis: | Recognition of conventional foreign antigen by T cells is determined by the expression of multiple variable regions of both alpha and beta chains of the T cell receptor (TCR) alpha/beta heterodimer. In contrast, there exists a class of antigens that appears to interact with the TCR alpha/beta heterodimer through the variable region on the beta chain (V beta), independent of other TCR components, a property that has led to their designation as superantigens. The goal of the present study was to analyze V alpha use in V beta 6+ T cells responsive to the superantigen, Mlaa. Results indicate that while deletion of T cells expressing V beta 6 in Mlsa-expressing mice is essentially complete and therefore appears to occur regardless of V alpha usage, in vitro Mlsa stimulation of T cells from Mlsa-negative mice results in significant skewing of V alpha use among responding V beta 6+ T cells. This indicates that V alpha expression influences recognition of the superantigen, Mlsa by mature peripheral T cells. |
| Databáze: | OpenAIRE |
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