Fetal lung development via quantitative biomarkers from diffusion MRI and histological validation in rhesus macaques
| Autor: | Nara S. Higano, Xuefeng Cao, Christopher D. Kroenke, Alyssa Filuta, Xiaojie Wang, Jason C. Woods, Jinbang Guo, James P. Bridges |
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| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty Fetus business.industry Obstetrics and Gynecology medicine.disease Macaca mulatta Article Fetal Development Pulmonary hypoplasia Diffusion Magnetic Resonance Imaging In vivo In utero Pediatrics Perinatology and Child Health medicine Animals Humans Gestation Biomarker (medicine) business Lung Biomarkers Ex vivo Diffusion MRI |
| Zdroj: | J Perinatol |
| ISSN: | 1476-5543 0743-8346 |
| Popis: | OBJECTIVE: To demonstrate sensitivity of diffusion-weighted MRI (DW-MRI) to pulmonary cellular-space changes during normal in-utero development using fetal rhesus macaques, compared to histological biomarkers. STUDY DESIGN: In-vivo/ex-vivo DW-MRI was acquired in 26 fetal rhesus lungs (early-canalicular through saccular stages). Apparent diffusion coefficients (ADC) from MRI and tissue area-density (H&E), alveolar type-II cells (ABCA3), and epithelial cells (TTF1) from histology were compared between gestational stages. RESULTS: In-vivo/ex-vivo ADC correlated with each other (Spearman ρ=0.47, P=0.038; Bland-Altman bias = 0.0835) and with area-density (in-vivo ρ=−0.56, P=0.011; ex-vivo ρ=−0.83, P |
| Databáze: | OpenAIRE |
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