The PI3K/AKT/mTOR signaling pathway inhibitors enhance radiosensitivity in cancer cell lines
| Autor: | Seyed Mohammad Abedi, Samaneh Vaseghi, Nasrin Abbasi Gharibkandi, Alireza Mardanshahi, Sajjad Molavipordanjani |
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| Rok vydání: | 2021 |
| Předmět: |
Cell Survival
medicine.medical_treatment Apoptosis Radiation Tolerance Phosphatidylinositol 3-Kinases Cell Line Tumor Neoplasms Autophagy Genetics medicine Humans Radiosensitivity Protein Kinase Inhibitors Molecular Biology Protein kinase B PI3K/AKT/mTOR pathway Cell Proliferation Phosphoinositide-3 Kinase Inhibitors Cell growth Akt/PKB signaling pathway business.industry TOR Serine-Threonine Kinases Cell Cycle Cancer MTOR Inhibitors General Medicine medicine.disease Radiation therapy Cancer research business Proto-Oncogene Proteins c-akt Signal Transduction |
| Zdroj: | Molecular Biology Reports. 48:1-14 |
| ISSN: | 1573-4978 0301-4851 |
| Popis: | INTRODUCTION Radiotherapy is one of the most common types of cancer treatment modalities. Radiation can affect both cancer and normal tissues, which limits the whole delivered dose. It is well documented that radiation activates phosphatidylinositol 3-kinase (PI3K) and AKT signaling pathway; hence, the inhibition of this pathway enhances the radiosensitivity of tumor cells. The mammalian target of rapamycin (mTOR) is a regulator that is involved in autophagy, cell growth, proliferation, and survival. CONCLUSION The inhibition of mTOR as a downstream mediator of the PI3K/AKT signaling pathway represents a vital option for more effective cancer treatments. The combination of PI3K/AKT/mTOR inhibitors with radiation can increase the radiosensitivity of malignant cells to radiation by autophagy activation. Therefore, this review aims to discuss the impact of such inhibitors on the cell response to radiation. |
| Databáze: | OpenAIRE |
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