Serrate1-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells
| Autor: | Gerard F. Hoyne, Jenny Dunne, Marta Corsin-Jimenez, Isabelle Le Roux, Margaret J. Dallman, Karen Tan, Jonathan R. Lamb, Michael John Owen, David Ish-Horowicz, L.M.G. Forsyth |
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| Rok vydání: | 2000 |
| Předmět: |
CD4-Positive T-Lymphocytes
Ovalbumin Immunology Antigen presentation Antigen-Presenting Cells Immune tolerance Epitopes Mice Immune Tolerance Immunology and Allergy Cytotoxic T cell Animals Humans Serrate-Jagged Proteins IL-2 receptor Antigens Dermatophagoides Antigen-presenting cell Cells Cultured Glycoproteins Immunity Cellular CD40 biology Receptors Notch Reverse Transcriptase Polymerase Chain Reaction Calcium-Binding Proteins Peripheral tolerance Membrane Proteins General Medicine Acquired immune system Cell biology Rats Gene Expression Regulation biology.protein Leukocytes Mononuclear Intercellular Signaling Peptides and Proteins Female Immunization Jagged-1 Protein Signal Transduction |
| Zdroj: | International immunology. 12(2) |
| ISSN: | 0953-8178 |
| Popis: | Signals derived from antigen-presenting cells (APC) influence the functional differentiation of CD4(+) T cells. We report here that Serrate1 (Jagged1), a ligand for the Notch1 receptor, may contribute to the differentiation of peripheral CD4(+) T cells into either helper or regulatory cells. Our findings demonstrate that antigen presented by murine APC overexpressing human Serrate1 induces naive peripheral CD4(+) T cells to become regulatory cells. These cells can inhibit primary and secondary immune responses, and transfer antigen-specific tolerance to recipient mice. Our results show that Notch signalling may help explain 'linked' suppression in peripheral tolerance, whereby tolerance induced to one epitope encompasses all epitopes on that antigen during the course of an immune response. |
| Databáze: | OpenAIRE |
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