Effect of Anesthetics on Acetylcholine Release from the Myoneural Junction
| Autor: | K. L. Dretchen, John P. Long, S. D. Gergis, M. D. Sokoll |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
medicine.drug_class
Guinea Pigs Neuromuscular Junction Neuromuscular transmission Motor nerve Pharmacology Synaptic Transmission General Biochemistry Genetics and Molecular Biology Rana Gastrocnemius muscle medicine Animals Thiopental Anesthetics Chemistry Rana pipiens Neuromuscular Blocking Agents Acetylcholine Stimulation Chemical Ethyl Ethers Curare Methoxyflurane Anesthesia Intravenous Ketamine Depressant Anura Anesthesia Inhalation Halothane Muscle Contraction medicine.drug |
| Zdroj: | Experimental Biology and Medicine. 141:629-631 |
| ISSN: | 1535-3699 1535-3702 |
| Popis: | It has been reported that diethyl ether as well as other intravenous and inhalation anesthetics have varying depressant actions on neuromuscular transmission (1-3). With respect to diethyl ether this has been ascribed to a curare like action on the postjuctional membrane (4, 5). However, in recent years curare as well as other competitive neuromuscular blocking agents have been shown to have depressant action on the motor nerve terminal resulting in reduction of acetylcholine output (6, 7).This work was conducted to elucidate the effects of some intravenous and inhalation anesthetics on acetylcholine output and thus gain a direct measure of activity on the nerve terminal. If they have a nerve terminal action, then they should reduce the amount of acetylcholine released upon nerve stimulation.Methods. Frog sciatic nerve gastrocnemius muscle preparation. Frogs weighing between 20 and 25 g of the species Rana pipiens were stunned and decapitated. The skin was removed exposing the gastrocnemius muscle. The sc... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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