Comparison of markers of ovarian reserve between patients with complete müllerian agenesis and age-matched fertile and infertile controls
| Autor: | Murat Ozekinci, Yeşim Şenol, Gulbahar Uzun, Munire Erman Akar, Sebahat Ozdem, Aylin Erman Daloglu, Gözde Öngüt |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Anti-Mullerian Hormone endocrine system medicine.medical_specialty 46 XX Disorders of Sex Development endocrine system diseases Congenital Abnormalities Cohort Studies Young Adult medicine Humans Outpatient clinic Prospective Studies Ovarian Reserve Ovarian reserve Prospective cohort study Mullerian Ducts health care economics and organizations Gynecology biology Female infertility Obstetrics and Gynecology Anti-Müllerian hormone medicine.disease Antral follicle female genital diseases and pregnancy complications humanities Müllerian agenesis Fertility Reproductive Medicine biology.protein Female Infertility Female Biomarkers Cohort study |
| Zdroj: | Fertility and Sterility. 104:176-179 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/j.fertnstert.2015.04.022 |
| Popis: | Objective To investigate ovarian reserve in complete mullerian agenesis (CMA) patients and to compare the ovarian reserve of CMA patients with that of age-matched fertile and infertile controls. Design Prospective cohort study. Setting University gynecology outpatient clinic. Patient(s) Fifty-eight typical CMA (type A) patients, 8 atypical CMA (type B) patients, 39 fertile patients, and 38 infertile patients were compared for ovarian reserve. Intervention(s) Ovarian reserve was evaluated via antimullerian hormone (AMH) levels and antral follicle counts (AFCs). Main Outcome Measure(s) Investigation of ovarian reserve in CMA patients and a comparison of the ovarian reserve of the CMA patients with that of age-matched fertile and infertile controls. Result(s) Fifty-eight type A and eight type B CMA patients and 39 fertile and 38 infertile control patients were assessed for ovarian reserve. The mean (±SD) ages of the type A and type B CMA patients and the fertile and infertile groups were 25.8 ± 5.3, 33.3 ± 5.9, 32.6 ± 4.8, and 33.9 ± 3.3 years, respectively. After age standardization of the groups, AMH levels and AFCs were found to be lower in the atypical CMA group. The differences in AMH levels and AFC were found to be highly significant. Conclusion(s) The present study showed that atypical CMA patients had decreased ovarian reserve compared with age-matched fertile and infertile controls. |
| Databáze: | OpenAIRE |
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