Clinical characteristics of anti-glutamic acid decarboxylase antibody-positive fulminant type 1 diabetes
| Autor: | Mitsuhiko Noda, Kazuyuki Inoue, Gen Mizutani, Yoichi Oikawa, Ikuo Inoue, Masako Hatano, Akira Shimada, Daigo Saito |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Fulminant 030209 endocrinology & metabolism Glutamic acid decarboxylase antibody Gastroenterology Body Mass Index Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine medicine Humans Insulin Autoantibodies Rank correlation Type 1 diabetes biology Glutamate Decarboxylase business.industry Middle Aged medicine.disease Titer Cross-Sectional Studies Diabetes Mellitus Type 1 030220 oncology & carcinogenesis biology.protein Ketone bodies Female Symptom Assessment Antibody business Body mass index |
| Zdroj: | Endocrine Journal. 66:329-336 |
| ISSN: | 1348-4540 0918-8959 |
| DOI: | 10.1507/endocrj.ej18-0417 |
| Popis: | This research aimed to examine the relationship between anti-glutamic acid decarboxylase antibody (GADA) titers and clinical parameters at onset and to clarify the association between clinical severity and GADA titers in GADA-positive fulminant type 1 diabetes. This cross-sectional observational study included 20 cases with GADA-positive fulminant type 1 diabetes (4 cases from our hospital and 16 from cases reported in the literature). The association between GADA titers and clinical parameters [age, sex, body weight, body mass index, period from appearance of any prodromal symptoms to diagnosis, period from development of hyperglycemic symptoms to diagnosis, GADA titer, HbA1c level, blood pH and HCO3- level, serum levels of ketone bodies and pancreatic exocrine enzymes] were analyzed. Spearman's rank correlation coefficient (rs) was used for the correlation analysis. The results showed that there was a significant inverse correlation between GADA titers and the "period from appearance of any prodromal symptoms to diagnosis" (rs = -0.559, p < 0.05). Moreover, GADA titers were inversely correlated with blood pH and HCO3- level (rs = -0.576, p < 0.05, rs = -0.578, p < 0.05, respectively), and positively correlated with serum levels of total ketone bodies, acetoacetate, and 3-hydroxybutyrate (rs = 0.661, p < 0.05; rs = 0.700, p < 0.05; and rs = 0.782, p < 0.01, respectively). These findings suggest that higher GADA titers may be linked to more severe clinical severity of GADA-positive fulminant type 1 diabetes at onset. This association may be attributed to possible pre-existence of autoimmunity-related β-cell damage before the onset of fulminant type 1 diabetes. |
| Databáze: | OpenAIRE |
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