Relationship of Genetic Variation in the Serotonin Transporter Gene (SLC6A4) and Congenital and Acquired Cardiovascular Diseases
| Autor: | W. Michael Hooten, Victor M. Karpyak, Magdalena Romanowicz, Gen Shinozaki, Rajeswari Avula, Simon Kung, Ann M. Moyer, Sandra C. Bryant, William J. Hogan, Kelly K. Edwards, James R. Rundell, Denise L. Walker, Mark R. Litzow, John L. Black, Sheila G. Jowsey-Gregoire, Maria I. Lapid, Linnea M. Baudhuin, Shawna L. Ehlers |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Tachycardia medicine.medical_specialty Population Polymorphism Single Nucleotide Gastroenterology Polymorphism (computer science) Internal medicine Genotype Genetic variation medicine Humans Genetic Predisposition to Disease Myocardial infarction education Genetics (clinical) Serotonin transporter Retrospective Studies Serotonin Plasma Membrane Transport Proteins education.field_of_study biology General Medicine Middle Aged medicine.disease Pulmonary hypertension Endocrinology Cardiovascular Diseases biology.protein Female medicine.symptom |
| Zdroj: | Genetic Testing and Molecular Biomarkers. 19:115-123 |
| ISSN: | 1945-0257 1945-0265 |
| DOI: | 10.1089/gtmb.2014.0250 |
| Popis: | Recent reports have suggested an association between variation in the serotonin transporter and primary pulmonary hypertension and myocardial infarction. We set out to determine whether these associations were present in a population of patients who underwent SLC6A4 genotyping and to explore whether genetic variation in the serotonin transporter might be also associated with other cardiovascular functional and structural abnormalities. Included were 3473 patients who were genotyped for the SLC6A4 5HTTLPR polymorphism and a subset for rs25531 (n=816) and STin2 (n=819). An association was observed between 5HTTLPR and primary pulmonary hypertension (p=0.0130), anomalies of the cerebrovascular system (p0.0001), and other anomalies of great veins (p=0.0359). The combined 5HTTLPR and rs25531 genotype was associated with tachycardia (p=0.0123). There was an association of the STin2 genotype with abnormal electrocardiogram (ECG) (p=0.0366) and abnormal cardiac study (0.0311). Overall, these results represent a step toward the understanding of the impact of SLC6A4 variation on cardiovascular pathology. |
| Databáze: | OpenAIRE |
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