Metals as radio-enhancers in oncology: The industry perspective
| Autor: | Agnès Pottier, Laurent Levy, Elsa Borghi |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Oncology
Radiation-Sensitizing Agents medicine.medical_specialty Radiotherapy medicine.medical_treatment Perspective (graphical) Radiation dose Biophysics Metal Nanoparticles Radiation beam Cell Biology Tumor control Biochemistry Radiation therapy Decision points Nanocapsules Neoplasms Internal medicine medicine Animals Humans Business Molecular Biology |
| Zdroj: | Biochemical and Biophysical Research Communications. 468:471-475 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2015.09.027 |
| Popis: | Radio-enhancers, metal-based nanosized agents, could play a key role in oncology. They may unlock the potential of radiotherapy by enhancing the radiation dose deposit within tumors when the ionizing radiation source is 'on', while exhibiting chemically inert behavior in cellular and subcellular systems when the radiation beam is 'off'. Important decision points support the development of these new type of therapeutic agents originated from nanotechnology. Here, we discuss from an industry perspective, the interest of developing radio-enhancer agents to improve tumor control, the relevance of nanotechnology to achieve adequate therapeutic attributes, and present some considerations for their development in oncology. |
| Databáze: | OpenAIRE |
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