Serum antioxidant vitamins and the risk of oral cancer in patients seen at a tertiary institution in Nigeria
| Autor: | A O Lawal, Effiong E. Akang, Lawoyin Jo, Bukola Folasade Adeyemi, Bamidele Kolude |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Vitamin medicine.medical_specialty Antioxidant medicine.medical_treatment Nigeria Ascorbic Acid Logistic regression Antioxidants chemistry.chemical_compound Risk Factors Internal medicine Odds Ratio medicine Humans Vitamin E Vitamin A Aged Aged 80 and over business.industry Cancer Avitaminosis Vitamins General Medicine Odds ratio Middle Aged medicine.disease Antioxidant vitamins Logistic Models chemistry Case-Control Studies Immunology Etiology Female Mouth Neoplasms business Cohort study |
| Zdroj: | Nigerian Journal of Clinical Practice; Vol 15, No 1 (2012) |
| ISSN: | 1119-3077 |
| Popis: | Objectives: Tobacco and alcohol are major risk factors of oral cancer, but nutritional deficiency may also contribute to development of oral cancer. This study compared serum antioxidant vitamin levels in oral cancer patients and controls in order to validate the role of vitamin deficiencies in the etiology of oral cancer. Materials and Methods: Serum vitamin A, C, and E levels of 33 oral cancer patients and 30 controls at University College Hospital, Ibadan, Nigeria, were determined using standard methods. The data obtained were analyzed using the Student t‑test, odds ratio, and logistic regression. Results: Mean vitamin A, C, and E levels were significantly lower in oral cancer patients (P=0.022, P=0.000, and P=0.013 respectively). Risk of oral cancer was 10.89, 11.35, and 5.6 times more in patients with low serum vitamins A, C, and E, respectively. However, on logistic regression analysis, only low serum vitamin E independently predicted occurrence of oral cancer. Conclusions: The lower serum vitamin A, C, and E levels in oral cancer patients could be either a cause or an effect of the oral cancer. Further studies using a larger sample size and cohort studies with long‑term follow‑up of subjects are desirable.Keywords: Antioxidant vitamins, Nigeria, oral cancer riskNigerian Journal of Clinical Practice •Jan-Mar 2012 • Vol 15 • Issue 1 |
| Databáze: | OpenAIRE |
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